Rheb - Ras homolog enriched in brain Gene

Also Known as Rheb1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19744

Summary

Enables GTP binding activity and protein kinase binding activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of TOR signaling. Acts upstream of or within positive regulation of oligodendrocyte differentiation. Part of spliceosomal complex. Is expressed in chondrocranium bone; nervous system; nucleus pulposus; and sensory organ. Orthologous to human RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Apr 2022]

Rheb Products (1)

mRNA Protein Name
NM_053075.3 NP_444305.2 GTP-binding protein Rheb

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
21336308 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21336308 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28242620 MGI
acts upstream of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
25411504 MGI
involved in positive regulation of TOR signaling IDA
IDA: Inferred from direct assay
21336308 MGI
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
12820960 MGI
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
21321084 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
25411504 MGI
involved in regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
19258434 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi membrane IDA
IDA: Inferred from direct assay
16631613 MGI
is active in endomembrane system IDA
IDA: Inferred from direct assay
16631613 MGI
part of spliceosomal complex IDA
IDA: Inferred from direct assay
11555636 MGI
is active in synapse EXP
EXP: Inferred from Experiment
25211037 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25211037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP-binding protein Rheb

  • RAS-homolog enriched in brain

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14530 Pelitrexol 98.07% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124798 Rheb inhibitor NR1 Inhibitor 99.26% Unkown
HY-172423 Darlifarnib Inhibitor / Unkown
HY-17654 BIEGi-1 Inhibitor / Unkown
HY-RS11942 RHEB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17646 Rheb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24106 Rheb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rheb NCBI NCBI:6009