CENPX - centromere protein X Gene

Also Known as D9; MHF2; CENP-X; FAAP10; STRA13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201254

About CENPX

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,018,703-82,022,878 (from NCBI)

This gene has 11 transcripts (splice variants) and 139 orthologues. Ubiquitous expression in prostate (RPKM 17.1), colon (RPKM 14.3) and 25 other tissues.

Summary

Enables DNA binding activity. Contributes to double-stranded DNA binding activity. Involved in replication fork processing and resolution of meiotic recombination intermediates. Part of FANCM-MHF complex and Fanconi anaemia nuclear complex. [provided by Alliance of Genome Resources, Apr 2022]

CENPX Products (4)

mRNA Protein Name
NM_001271006.2 NP_001257935.1 centromere protein X isoform 1
NM_001271007.2 NP_001257936.1 centromere protein X isoform 3
NM_001330536.2 NP_001317465.1 centromere protein X isoform 4
NM_144998.4 NP_659435.2 centromere protein X isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
20347429 GOA
contributes to double-stranded DNA binding IDA
IDA: Inferred from direct assay
20347428 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20347429 GOA
Biological Process GO Annotation Evidence References Source
involved in interstrand cross-link repair IDA
IDA: Inferred from direct assay
20347429 GOA
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
20347428 GOA
involved in resolution of meiotic recombination intermediates IMP
IMP: Inferred from mutant phenotype
20347428 GOA
Cellular Component GO Annotation Evidence References Source
part of FANCM-MHF complex IDA
IDA: Inferred from direct assay
20347428 GOA
part of FANCM-MHF complex IPI
IPI: Inferred from physical interaction
20347429 GOA
part of Fanconi anaemia nuclear complex IDA
IDA: Inferred from direct assay
20347428 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20347429 GOA
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPX Protein Structure

CENP-X

CENP-X: CENP-S associating Centromere protein X (12 - 81)

  • 0
  • 81 a.a.
Protein Preferred Names Protein Names

centromere protein X

  • FANCM associated histone fold protein 2

CENPX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CENPX A8MT69 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra
CENPX A8MT69 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
CENPX A8MT69 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
CENPX A8MT69 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
CENPX A8MT69 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
CENPX A8MT69 CENPS Homo sapiens Q8N2Z9
SAXS
23886707
Intra
CENPX A8MT69 CENPS Homo sapiens Q8N2Z9
GMS
22304917
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02495 CENPX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22433 Cenpx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28956 Cenpx Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CENPX MGD MGI:894324
Rattus norvegicus CENPX RGD RGD:1590057
Macaca mulatta CENPX VGNC VGNC:70934
Bos taurus CENPX VGNC VGNC:27188
Others CENPX NCBI