Ccl11 - chemokine (C-C motif) ligand 11 Gene

Also Known as Scya11; eotaxin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20292

Summary

Predicted to enable CCR3 Chemokine Receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; endocardial lining; liver parenchyma; liver vasculature; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11). [provided by Alliance of Genome Resources, Apr 2022]

Ccl11 Products (1)

mRNA Protein Name
NM_011330.3 NP_035460.1 eotaxin precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
10804170 MGI
involved in learning or memory IDA
IDA: Inferred from direct assay
21886162 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: Inferred from mutant phenotype
10804170 MGI
involved in negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
21886162 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19525930 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eotaxin

  • C-C motif chemokine 11

  • eosinophil chemotactic protein

  • small chemokine (C-C motif) ligand 11

  • small-inducible cytokine A11

Recombinant Ccl11 Proteins

Cat. No. Product Name Accession Purity
HY-P7160 Eotaxin/CCL11 Protein, Mouse P48298 (H24-P97) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99474 Bertilimumab Inhibitor 97.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2609 7,4'-Dihydroxyflavone Inhibitor 99.64% Unkown
HY-103361 SB297006 Antagonist 99.86% Unkown
HY-110295 SPL-334 Inhibitor 99.6% Unkown
HY-111198 YM-355179 fumarate / Unkown
HY-RS02081 CCL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174771 Human CCL11 mRNA / Unkown
HY-RS16897 Ccl11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23339 Ccl11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl11 NCBI NCBI:6356