Slc2a2 - solute carrier family 2 (facilitated glucose transporter), member 2 Gene

Also Known as Glut2; Glut-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20526

About Slc2a2

Chromosome 3: 28,752,052-28,785,508 forward strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 312 orthologues, 11 paralogues and is associated with 20 phenotypes. Biased expression in liver adult (RPKM 5.7), liver E18 (RPKM 37.6) and 7 other tissues.

Summary

Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Located in several cellular components, including apical plasma membrane; brush border; and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; liver; metanephros; and testis. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a2 Products (1)

mRNA Protein Name
NM_031197.2 NP_112474.2 solute carrier family 2, facilitated glucose transporter member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-glucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
10823833 MGI
enables dehydroascorbic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
18668520 MGI
Biological Process GO Annotation Evidence References Source
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
18668520 MGI
involved in dehydroascorbic acid transport IDA
IDA: Inferred from direct assay
18668520 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
10823833 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19841136 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
11287626 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18668520 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12921743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a2 Protein Structure

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (11 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

solute carrier family 2, facilitated glucose transporter member 2

  • glucose transporter type 2, liver

  • liver-type glucose transporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13164 SLC2A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13165 Slc2a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13166 Slc2a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc2a2 NCBI NCBI:6514