STX2 - syntaxin 2 Gene

Also Known as EPM; EPIM; STX2A; STX2B; STX2C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2054

About STX2

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,789,600-130,839,250 (from NCBI)

This gene has 13 transcripts (splice variants), 254 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 4.3), lung (RPKM 3.9) and 25 other tissues.

Summary

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

STX2 Products (9)

mRNA Protein Name
NM_001351049.2 NP_001337978.2 syntaxin-2 isoform 3
NM_001351050.2 NP_001337979.1 syntaxin-2 isoform 4
NM_001351051.2 NP_001337980.1 syntaxin-2 isoform 5
NM_001351052.2 NP_001337981.1 syntaxin-2 isoform 6
NM_001413773.1 NP_001400702.1 syntaxin-2 isoform 7
NM_001413774.1 NP_001400703.1 syntaxin-2 isoform 8
NM_001413775.1 NP_001400704.1 syntaxin-2 isoform 2
NM_001980.5 NP_001971.2 syntaxin-2 isoform 1
NM_194356.4 NP_919337.1 syntaxin-2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12773094 GOA
enables structural molecule activity IDA
IDA: Inferred from direct assay
22226963 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
22226963 GOA
involved in cornified envelope assembly IDA
IDA: Inferred from direct assay
22226963 GOA
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16339081 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
22226963 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
21720706 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21720706 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
22226963 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX2 Protein Structure

Syntaxin

Syntaxin: Syntaxin (28 - 130)

SNARE

SNARE: SNARE domain (197 - 258)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

syntaxin-2

  • epimorphin

Related Diseases

Diseases Alias
Acute Diarrhea
Dysentery

  • Infectious Diarrhea
Campylobacteriosis

  • Campylobacter Infections

  • Campylobacter Infection

  • Enteric Campylobacteriosis
Shigellosis

  • Dysentery, Bacillary

  • Bacillary Dysentery

  • Shigella Boydii Infectious Disease

  • Shigella Flexneri Infectious Disease

  • Shigella Gastroenteritis

  • Shigella Sonnei Infectious Disease

  • Shigella Infections
Urinary Tract Infection

  • Urinary Tract Infections

  • Uti

  • Urinary Tract Infection Nos

  • Uti - [Urinary Tract Infection]

  • Uti Nos - [Urinary Tract Infection Nos]

  • Urosepsis Nos

  • E Coli Uti

  • E Coli Urinary Tract Infection

  • Escherichia Coli Uti
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2764 Apyrase / Unkown
HY-RS13982 STX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11232 NAB815 Inhibitor / Unkown
HY-122740 Retro-1 / Unkown
HY-RS18975 Stx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25464 Stx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus STX2 VGNC VGNC:35438
Rattus norvegicus STX2 RGD RGD:2558
Canis familiaris STX2 VGNC VGNC:49890
Felis catus STX2 VGNC VGNC:65812
Mus musculus STX2 MGD MGI:108059
Macaca mulatta STX2 VGNC VGNC:78259
Others STX2 NCBI