Mettl14 - methyltransferase like 14 Gene

Also Known as mKIAA1627; G430022H21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 210529

Summary

Enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in several processes, including forebrain radial glial cell differentiation; mRNA destabilization; and mRNA metabolic process. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Mettl14 Products (1)

mRNA	Protein	Name
NM_201638.2	NP_964000.2	N6-adenosine-methyltransferase non-catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA m(6)A methyltransferase activity	IDA IDA: Inferred from direct assay	24394384	MGI
enables mRNA m(6)A methyltransferase activity	IMP IMP: Inferred from mutant phenotype	31340148	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24394384	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in RNA methylation	IMP IMP: Inferred from mutant phenotype	28914256	MGI
involved in forebrain radial glial cell differentiation	IMP IMP: Inferred from mutant phenotype	28965759	MGI
involved in gliogenesis	IMP IMP: Inferred from mutant phenotype	28965759	MGI
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	24394384	MGI
involved in mRNA modification	IMP IMP: Inferred from mutant phenotype	31340148	MGI
involved in mRNA processing	IDA IDA: Inferred from direct assay	24394384	MGI
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	29290617	MGI
acts upstream of negative regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	29290617	MGI
acts upstream of positive regulation of translation	IDA IDA: Inferred from direct assay	29290617	MGI
involved in regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	31340148	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28914256	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	24394384	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	29290617	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	24394384	MGI
located in nucleus	IDA IDA: Inferred from direct assay	28914256	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
N6-adenosine-methyltransferase non-catalytic subunit	N6-adenosine-methyltransferase subunit METTL14 methyltransferase-like protein 14 snoRNA MBII-84

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19528	SAH		99.90%	Unkown
HY-160415A	WD6305 TFA		99.81%	Unkown
HY-W037893	CHMA1004 dihydrochloride	Activator	99.38%	Unkown
HY-N0353	Curdione	Inhibitor	99.80%	Unkown
HY-19528S	SAH-d4		≥99.0%	Unkown
HY-160415	WD6305		98.98%	Unkown
HY-P10387	RSM3		95.73%	Unkown
HY-RS08355	METTL14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153625	STM2120	Inhibitor	99.19%	Unkown
HY-P10387A	RSM3 TFA		98.83%	Unkown
HY-RS16861	Mettl14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-151926	Antiviral agent 24	Inhibitor	99.63%	Unkown
HY-162930	PROTAC METTL3 degrader 1	Degrader	/	Unkown
HY-19528S2	SAH-13C10		99.90%	Unkown
HY-183186	EP102	Inhibitor	/	Unkown
HY-151924	Antiviral agent 23	Inhibitor	/	Unkown
HY-162282	PROTAC METTL3-14 degrader 1	Degrader	/	Unkown
HY-W125425	CHMA1004	Activator	/	Unkown
HY-RS23302	Mettl14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mettl14	NCBI	NCBI:57721