Brcc3 - BRCA1/BRCA2-containing complex, subunit 3 Gene

Also Known as C6.1A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 210766

Summary

Predicted to enable enzyme regulator activity; peptidase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within response to X-ray. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin Ligase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Brcc3 Products (5)

mRNA Protein Name
NM_001166457.1 NP_001159929.1 lys-63-specific deubiquitinase BRCC36
NM_001166459.1 NP_001159931.1 lys-63-specific deubiquitinase BRCC36
NM_001358736.1 NP_001345665.1 lys-63-specific deubiquitinase BRCC36
NM_001358737.1 NP_001345666.1 lys-63-specific deubiquitinase BRCC36
NM_145956.4 NP_666068.1 lys-63-specific deubiquitinase BRCC36

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables metal-dependent deubiquitinase activity IDA
IDA: Inferred from direct assay
23246432 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22974638 MGI
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
34180153 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
23246432 MGI
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
23246432 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lys-63-specific deubiquitinase BRCC36

  • 6.1A protein

  • BRCA1-A complex subunit BRCC36

  • BRCA1/BRCA2-containing complex subunit 36

  • BRISC complex subunit BRCC36

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01595 BRCC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03694 DEPDC1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17602 Brcc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24062 Brcc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brcc3 NCBI NCBI:79184