Tnfsf11 - tumor necrosis factor (ligand) superfamily, member 11 Gene

Also Known as ODF; OPGL; RANKL; Ly109l; Trance

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21943

About Tnfsf11

Chromosome 14: 78,514,885-78,545,483 reverse strand.GRCm39:CM001007.3

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 95 phenotypes. Biased expression in thymus adult (RPKM 1.), mammary gland adult (RPKM .5) and 8 other tissues.

Summary

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf11 Products (1)

mRNA Protein Name
NM_011613.4 NP_035743.2 tumor necrosis factor ligand superfamily member 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
11859102 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11859102 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
19298785 MGI
enables tumor necrosis factor receptor superfamily binding IPI
IPI: Inferred from physical interaction
9367155 MGI
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19252502 MGI
acts upstream of JNK cascade IGI
IGI: Inferred from genetic interaction
22073305 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9950424 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of or within bone resorption IDA
IDA: Inferred from direct assay
12490655 MGI
acts upstream of or within calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
21982707 MGI
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
24039232 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
11051546 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11051546 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
27336669 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
9950424 MGI
acts upstream of or within osteoclast development IDA
IDA: Inferred from direct assay
21841309 MGI
acts upstream of osteoclast differentiation IDA
IDA: Inferred from direct assay
15724149 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: Inferred from direct assay
14662855 MGI
acts upstream of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
17053831 MGI
acts upstream of or within osteoclast differentiation IGI
IGI: Inferred from genetic interaction
15485831 MGI
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
15750601 MGI
acts upstream of or within osteoclast proliferation IDA
IDA: Inferred from direct assay
22451653 MGI
acts upstream of or within paracrine signaling IDA
IDA: Inferred from direct assay
24190884 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
11051546 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19940926 MGI
acts upstream of or within positive regulation of JNK cascade IGI
IGI: Inferred from genetic interaction
22073305 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
19298785 MGI
involved in positive regulation of corticotropin-releasing hormone secretion IDA
IDA: Inferred from direct assay
19940926 MGI
involved in positive regulation of fever generation by positive regulation of prostaglandin secretion IDA
IDA: Inferred from direct assay
19940926 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
17442941 MGI
acts upstream of or within positive regulation of osteoclast development IDA
IDA: Inferred from direct assay
18269914 MGI
acts upstream of or within positive regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
15657444 MGI
acts upstream of or within positive regulation of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
17053831 MGI
involved in positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
23478294 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
11051546 MGI
involved in positive regulation of phosphorylation IDA
IDA: Inferred from direct assay
19252502 MGI
acts upstream of or within regulation of actin binding IDA
IDA: Inferred from direct assay
19715671 MGI
acts upstream of or within regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
12490655 MGI
acts upstream of or within tooth eruption IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
17442941 MGI
involved in tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
19940926 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnfsf11 Protein Structure

TNF

TNF: pfam00229 (183 - 311)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 11

  • OPG ligand

  • TNF-related activation-induced cytokine

  • osteoclast differentiation factor

  • osteoprotegerin ligand

  • receptor activator of NF-kappaB ligand

  • receptor activator of nuclear factor kappa-B ligand

  • tumor necrosis factor-related activation-induced cytokine

Recombinant Tnfsf11 Proteins

Cat. No. Product Name Accession Purity
HY-P7425 RANKL/TNFSF11 Protein, Mouse O35235-1 (Q137-D316) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73388 RANKL/TNFSF11 Protein, Mouse (HEK293, Fc) AAC40113.1/ O35235-1(R72-D316) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700226AF Animal-Free RANKL/TNFSF11 Protein, Mouse (His) O35235-1 (P143-D316) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7425B RANKL/TNFSF11 Protein, Mouse (HEK293, N-His) O35235-1 (R72-D316) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P9958A Denosumab (anti-TNFSF11) Inhibitor 99.9% Phase 4

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14819 TNFSF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14820 Tnfsf11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14821 TNFSF11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991362 GB-223 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf11 NCBI NCBI:8600