2. Gene
  3. Tnfsf11 - tumor necrosis factor (ligand) superfamily, member 11 Gene

Tnfsf11 - tumor necrosis factor (ligand) superfamily, member 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ODF; OPGL; RANKL; Ly109l; Trance

Gene ID: 21943 | Gene type: protein coding

About Tnfsf11

Chromosome 14: 78,514,885-78,545,483 reverse strand.GRCm39:CM001007.3

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 95 phenotypes. Biased expression in thymus adult (RPKM 1.), mammary gland adult (RPKM .5) and 8 other tissues.

Summary

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf11 Products(1)

mRNA Protein Name
NM_011613.4 NP_035743.2 tumor necrosis factor ligand superfamily member 11

Tnfsf11 Protein Structure

TNF

TNF: pfam00229 (183 - 311)

  • 0
  • 100
  • 200
  • 316 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 11

OPG ligand

TNF-related activation-induced cytokine

osteoclast differentiation factor

osteoprotegerin ligand

receptor activator of NF-kappaB ligand

receptor activator of nuclear factor kappa-B ligand

tumor necrosis factor-related activation-induced cytokine

Recombinant Tnfsf11 Proteins

Cat. No. Product Name Accession Purity
HY-P7425 RANKL/TNFSF11 Protein, Mouse O35235-1 (Q137-D316) ≥95%
HY-P7425A RANKL/TNFSF11 Protein, Mouse (HEK293, His) O35235 (R72-D316) ≥95%
HY-P73388 RANKL/TNFSF11 Protein, Mouse (HEK293, Fc) AAC40113.1 (R72-D316) ≥95%
HY-P700226AF Animal-Free RANK L/TNFSF11 Protein, Mouse (His) O35235 (P143-D316) ≥95%
HY-P7425B RANK L/TNFSF11 Protein, Mouse (HEK293, N-His) O35235 (R72-D316) ≥95%
HY-P700259 RANKL/TNFSF11 Protein, Mouse (CHO, His) O35235 (R72-D316) ≥95%

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9958 Denosumab Inhibitor ≥99.0% Unkown
Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P9958A Denosumab (anti-TNFSF11) 95.00% Phase 4
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14819 TNFSF11 Human Pre-designed siRNA Set A / Unkown
HY-RS14820 Tnfsf11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14821 TNFSF11 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf11 NCBI NCBI:8600
Macaca fascicularis Tnfsf11 NCBI NCBI:102137946