Tsc2 - TSC complex subunit 2 Gene

Also Known as Tcs2; Nafld

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22084

Summary

Enables 14-3-3 protein binding activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; intracellular signal transduction; and negative regulation of intracellular signal transduction. Located in cytoplasm. Is active in synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Tsc2 Products (24)

mRNA Protein Name
NM_001039363.3 NP_001034452.1 tuberin isoform 2
NM_001286713.2 NP_001273642.1 tuberin isoform 3
NM_001286714.2 NP_001273643.1 tuberin isoform 1
NM_001286716.2 NP_001273645.1 tuberin isoform 2
NM_001286718.2 NP_001273647.1 tuberin isoform 4
NM_001286720.2 NP_001273649.1 tuberin isoform 5
NM_001403402.1 NP_001390331.1 tuberin isoform 16
NM_001403403.1 NP_001390332.1 tuberin isoform 17
NM_001403404.1 NP_001390333.1 tuberin isoform 17
NM_001403405.1 NP_001390334.1 tuberin isoform 16
NM_001403406.1 NP_001390335.1 tuberin isoform 15
NM_001403407.1 NP_001390336.1 tuberin isoform 14
NM_001403408.1 NP_001390337.1 tuberin isoform 13
NM_001403409.1 NP_001390338.1 tuberin isoform 12
NM_001403410.1 NP_001390339.1 tuberin isoform 11
NM_001403411.1 NP_001390340.1 tuberin isoform 11
NM_001403412.1 NP_001390341.1 tuberin isoform 10
NM_001403413.1 NP_001390342.1 tuberin isoform 9
NM_001403414.1 NP_001390343.1 tuberin isoform 6
NM_001403415.1 NP_001390344.1 tuberin isoform 8
NM_001403416.1 NP_001390345.1 tuberin isoform 7
NM_001403417.1 NP_001390346.1 tuberin isoform 4
NM_001403418.1 NP_001390347.1 tuberin isoform 6
NM_011647.4 NP_035777.2 tuberin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
18198340 MGI
enables GTPase activator activity IDA
IDA: Inferred from direct assay
12820960 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11741832 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell proliferation IGI
IGI: Inferred from genetic interaction
16027169 MGI
acts upstream of or within D-glucose import IMP
IMP: Inferred from mutant phenotype
18511518 MGI
acts upstream of T cell proliferation IGI
IGI: Inferred from genetic interaction
16027169 MGI
involved in anoikis IMP
IMP: Inferred from mutant phenotype
23778976 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16027168 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10096549 MGI
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
18511518 MGI
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
24529379 MGI
involved in excitatory chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
30679017 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
10096549 MGI
involved in inhibitory chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
30679017 MGI
acts upstream of or within negative regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
16027169 MGI
acts upstream of or within negative regulation of T cell proliferation IGI
IGI: Inferred from genetic interaction
16027169 MGI
involved in negative regulation of TOR signaling IGI
IGI: Inferred from genetic interaction
23778976 MGI
acts upstream of or within negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
18198340 MGI
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
12820960 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
23878245 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16027168 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10096549 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16027169 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16027169 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
15249583 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
10096549 MGI
acts upstream of or within positive chemotaxis IMP
IMP: Inferred from mutant phenotype
15249583 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23878245 MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15249583 MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15249583 MGI
acts upstream of or within positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
20453062 MGI
involved in positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
23778976 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23858058 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
10827137 MGI
acts upstream of or within protein localization IDA
IDA: Inferred from direct assay
11741832 MGI
acts upstream of or within protein transport into plasma membrane raft IMP
IMP: Inferred from mutant phenotype
18511518 MGI
acts upstream of or within regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
10827137 MGI
acts upstream of or within regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12403809 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
18198340 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23858058 MGI
Cellular Component GO Annotation Evidence References Source
part of TSC1-TSC2 complex IDA
IDA: Inferred from direct assay
12820960 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11741832 MGI
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
24529379 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tuberin

  • tuberous sclerosis 2 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150229 306-N16B 99.27% Unkown
HY-134904 RMC-6272 Inhibitor 97.42% Unkown
HY-RS15132 TSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23540 Tsc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134922 NS1-IN-1 Inhibitor / Unkown
HY-155475 mTORC1-IN-2 Inhibitor / Unkown
HY-RS17096 Tsc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tsc2 NCBI NCBI:7249