Tshr - thyroid stimulating hormone receptor Gene

Also Known as hyt; pet; hypothroid

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22095

About Tshr

Chromosome 12: 91,351,337-91,516,582 forward strand.GRCm39:CM001005.3

This gene has 5 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 66 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 19.7), genital fat pad adult (RPKM 11.8) and 3 other tissues.

Summary

Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in bladder; renal vasculature; thyroid gland; and thyroid gland lobe. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tshr Products (2)

mRNA Protein Name
NM_011648.5 NP_035778.3 thyrotropin receptor isoform 1 precursor
NM_001113404.1 NP_001106875.1 thyrotropin receptor isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables thyroid-stimulating hormone receptor activity IDA
IDA: Inferred from direct assay
7789342 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
9300691 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11440271 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
11530227 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
10575115 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
10575115 MGI
acts upstream of or within inner ear receptor cell development IMP
IMP: Inferred from mutant phenotype
10575115 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
10575115 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
18559984 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
11530227 MGI
acts upstream of or within regulation of locomotion IMP
IMP: Inferred from mutant phenotype
11530227 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
7789342 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tshr Protein Structure

LRR_RI

LRR_RI: sd00033 (53 - 76)

LRR_5

LRR_5: cl37855 (64 - 220)

LRR_RI

LRR_RI: sd00033 (77 - 101)

LRR_RI

LRR_RI: sd00033 (102 - 126)

LRR_RI

LRR_RI: sd00033 (127 - 151)

LRR_RI

LRR_RI: sd00033 (152 - 176)

LRR_RI

LRR_RI: sd00033 (180 - 200)

LRR_RI

LRR_RI: sd00033 (201 - 225)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (414 - 688)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (415 - 441)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (448 - 473)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (493 - 523)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (535 - 557)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (577 - 606)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (616 - 646)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (656 - 681)

  • 0
  • 200
  • 400
  • 600
  • 764 a.a.
Protein Preferred Names Protein Names

thyrotropin receptor

  • TSH-R

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107916 Thyrotropin Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12381 ML224 Antagonist 99.18% Unkown
HY-114116 ML-109 Agonist 99.02% Unkown
HY-N0526 2"-O-Galloylhyperin 99.57% Unkown
HY-158100 SYD5115 Antagonist 99.69% Unkown
HY-114918 MS438 Agonist 99.85% Unkown
HY-150210 FSHR agonist 1 Agonist 99.45% Unkown
HY-18286 NCGC00229600 Antagonist 99.67% Unkown
HY-129995A TSHR antagonist S37a Antagonist 98.22% Unkown
HY-114994 MS437 Activator 99.41% Unkown
HY-122974 VA-K-14 hydrochloride Antagonist 98.96% Unkown
HY-124867 D3-βArr Modulator 99.49% Unkown
HY-100271 Org41841 Agonist 99.77% Unkown
HY-W331198 Tralopyril Inducer 99.70% Unkown
HY-153213A Org 274178-0 Antagonist 99.40% Unkown
HY-129995 TSHR antagonist S37b Inhibitor 99.06% Unkown
HY-169054 NCATS-SM4420 / Unkown
HY-182705 Org 214444-0 / Unkown
HY-RS15145 TSHR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15146 Tshr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15147 Tshr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180862 TSHR modulator-1 / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991202 Anti-TSHR Antibody (M22) 99.46% Unkown
HY-P990534 Anti-TSHR Antibody (K1-70) Inhibitor 98.57% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tshr NCBI NCBI:7253