Vamp2 - vesicle-associated membrane protein 2 Gene

Also Known as Syb2; Syb-2; sybII; Vamp-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22318

Summary

Enables Calmodulin binding activity; phospholipid binding activity; and syntaxin-1 binding activity. Involved in secretion by cell and synaptic vesicle endocytosis. Acts upstream of or within several processes, including Golgi to plasma membrane protein transport; cellular response to Insulin stimulus; and long-term synaptic potentiation. Located in several cellular components, including secretory vesicle; storage vacuole; and trans-Golgi network. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vamp2 Products (1)

mRNA Protein Name
NM_009497.3 NP_033523.1 vesicle-associated membrane protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
12145198 MGI
enables calmodulin binding IDA
IDA: Inferred from direct assay
12145198 MGI
enables phospholipid binding IDA
IDA: Inferred from direct assay
12145198 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10394363 MGI
enables syntaxin binding IPI
IPI: Inferred from physical interaction
17548353 MGI
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
18703708 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Golgi to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
20582536 MGI
acts upstream of or within calcium-ion regulated exocytosis IDA
IDA: Inferred from direct assay
12145198 MGI
acts upstream of or within calcium-ion regulated exocytosis IMP
IMP: Inferred from mutant phenotype
15920476 MGI
acts upstream of or within cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
18227281 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15920476 MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
IDA: Inferred from direct assay
23395379 MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
23395379 MGI
involved in hormone secretion IDA
IDA: Inferred from direct assay
24356748 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
23395379 MGI
acts upstream of or within membrane fusion IMP
IMP: Inferred from mutant phenotype
15920476 MGI
acts upstream of or within positive regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
18227281 MGI
involved in regulated exocytosis IDA
IDA: Inferred from direct assay
24356748 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: Inferred from direct assay
12145198 MGI
acts upstream of or within regulation of vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
18227281 MGI
involved in synaptic vesicle docking IDA
IDA: Inferred from direct assay
25374362 MGI
involved in synaptic vesicle docking IMP
IMP: Inferred from mutant phenotype
25374362 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
15475946 MGI
acts upstream of or within synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
11691998 MGI
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
15475946 MGI
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
23395379 MGI
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
23395379 MGI
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
18535671 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24356748 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
18505797 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
12490950 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23395379 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23395379 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18827011 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18505797 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
12145198 MGI
located in storage vacuole IDA
IDA: Inferred from direct assay
21828338 MGI
located in synapse IDA
IDA: Inferred from direct assay
18706977 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
15145078 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
12192047 MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
IDA: Inferred from direct assay
21040848 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
18827011 MGI
located in vesicle IDA
IDA: Inferred from direct assay
17313651 MGI
located in zymogen granule membrane IDA
IDA: Inferred from direct assay
12192047 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 2

  • synaptobrevin II

  • synaptobrevin-2

  • vesicle-associated membrane 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5366 PEP1 Modulator 99.88% Unkown
HY-RS15594 VAMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21080 Vamp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27597 Vamp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp2 NCBI NCBI:6844