Rorb - RAR-related orphan receptor beta Gene

Also Known as RZRB; hstp; Nr1f2; Rorbeta; RZR-beta

Species: Mus musculus

Gene Type: protein coding

Gene ID: 225998

About Rorb

Chromosome 19: 18,907,969-19,088,560 reverse strand.GRCm39:CM001012.3

This gene has 5 transcripts (splice variants), 398 orthologues, 19 paralogues and is associated with 36 phenotypes. Biased expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 2.8) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rorb Products (3)

mRNA	Protein	Name
NM_001043354.2	NP_001036819.1	nuclear receptor ROR-beta isoform 1
NM_001289921.1	NP_001276850.1	nuclear receptor ROR-beta isoform 3
NM_146095.4	NP_666207.3	nuclear receptor ROR-beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16574740	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16574740	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23652001	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16574740	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10860982	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16574740	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	23652001	MGI
involved in eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	16574740	MGI
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	22189870	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16574740	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16574740	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	17303680	MGI
involved in retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	23652001	MGI
involved in retinal cone cell development	IDA IDA: Inferred from direct assay	16574740	MGI
involved in retinal rod cell development	IMP IMP: Inferred from mutant phenotype	16574740	MGI
acts upstream of or within retinal rod cell differentiation	IMP IMP: Inferred from mutant phenotype	25296752	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16574740	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rorb Protein Structure

NR_DBD_ROR

NR_LBD_ROR_like

0
100
200
300
400
459 a.a.

Protein Preferred Names	Protein Names
nuclear receptor ROR-beta	nuclear receptor RZR-beta nuclear receptor subfamily 1 group F member 2 retinoid-related orphan receptor-beta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12129	RORB Human Pre-designed siRNA Set A		/	Unkown
HY-RS12130	Rorb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS12131	Rorb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rorb	NCBI	NCBI:6096