P2rx2 - purinergic receptor P2X, ligand-gated ion channel, 2 Gene

Also Known as P2x2; P2X2a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231602

About P2rx2

Chromosome 5: 110,487,678-110,491,078 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 8 phenotypes. Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues.

Summary

Enables extracellularly ATP-gated cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including response to ATP; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]

P2rx2 Products (5)

mRNA Protein Name
NM_001164834.1 NP_001158306.1 P2X purinoceptor 2 isoform c
NM_001310700.1 NP_001297629.1 P2X purinoceptor 2 isoform d
NM_001164833.1 NP_001158305.1 P2X purinoceptor 2 isoform b
NM_153400.4 NP_700449.2 P2X purinoceptor 2 isoform a
NM_001310701.1 NP_001297630.1 P2X purinoceptor 2 isoform e

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
12917379 MGI
enables extracellularly ATP-gated monoatomic cation channel activity IGI
IGI: Inferred from genetic interaction
15081800 MGI
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
15081800 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IGI
IGI: Inferred from genetic interaction
15961431 MGI
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
15961431 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12917379 MGI
acts upstream of or within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling IMP
IMP: Inferred from mutant phenotype
14672995 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
17706883 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
12937291 MGI
acts upstream of or within peristalsis IMP
IMP: Inferred from mutant phenotype
12937291 MGI
acts upstream of or within response to ATP IGI
IGI: Inferred from genetic interaction
15961431 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
15572362 MGI
acts upstream of or within response to carbohydrate IMP
IMP: Inferred from mutant phenotype
16322458 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
14672995 MGI
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
23345450 MGI
acts upstream of or within sensory perception of taste IGI
IGI: Inferred from genetic interaction
16322458 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
17706883 MGI
acts upstream of or within urinary bladder smooth muscle contraction IGI
IGI: Inferred from genetic interaction
15961431 MGI
acts upstream of or within urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
15961431 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
15961431 MGI
is active in neuronal dense core vesicle EXP
EXP: Inferred from Experiment
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
21321602 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17706883 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx2 Protein Structure

P2X

P2X: TIGR00863 (13 - 379)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09900 P2RX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09901 P2rx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09902 P2rx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx2 NCBI NCBI:22953