Palb2 - partner and localizer of BRCA2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233826

Summary

Predicted to enable DNA binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and post-anal tail morphogenesis. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; breast cancer; and pancreatic Cancer. Orthologous to human PALB2 (partner and localizer of BRCA2). [provided by Alliance of Genome Resources, Apr 2022]

Palb2 Products (5)

mRNA Protein Name
NM_001081238.2 NP_001074707.1 partner and localizer of BRCA2 isoform 1
NM_001289842.1 NP_001276771.1 partner and localizer of BRCA2 isoform 2
NM_001289843.1 NP_001276772.1 partner and localizer of BRCA2 isoform 3
NM_001289844.1 NP_001276773.1 partner and localizer of BRCA2 isoform 4
NM_001289845.1 NP_001276774.1 partner and localizer of BRCA2 isoform 5

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
20484223 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
21404276 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
23657012 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
23657012 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
20484223 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
20484223 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23657012 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21404276 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
20484223 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
20484223 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

partner and localizer of BRCA2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10002 PALB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19226 Palb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25715 Palb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Palb2 NCBI NCBI:79728