Piezo1 - piezo-type mechanosensitive ion channel component 1 Gene

Also Known as Fam38a; mKIAA0233; 9630020g22

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234839

Summary

Enables identical protein binding activity and mechanosensitive cation channel activity. Involved in positive regulation of myotube differentiation. Acts upstream of or within cation transport; detection of mechanical stimulus; and regulation of membrane potential. Located in plasma membrane. Is expressed in several structures, including hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1). [provided by Alliance of Genome Resources, Apr 2022]

Piezo1 Products (2)

mRNA Protein Name
NM_001037298.1 NP_001032375.1 piezo-type mechanosensitive ion channel component 1 isoform 2
NM_001357349.1 NP_001344278.1 piezo-type mechanosensitive ion channel component 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22343900 MGI
enables mechanosensitive monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
32142647 MGI
enables mechanosensitive monoatomic ion channel activity IDA
IDA: Inferred from direct assay
20813920 MGI
enables mechanosensitive monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
38228630 MGI
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
20813920 MGI
enables monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
20813920 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24157948 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of mechanical stimulus IMP
IMP: Inferred from mutant phenotype
20813920 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
32142647 MGI
involved in monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
20813920 MGI
involved in positive regulation of myotube differentiation IMP
IMP: Inferred from mutant phenotype
29799007 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
20813920 MGI
Cellular Component GO Annotation Evidence References Source
located in cuticular plate IDA
IDA: Inferred from direct assay
38228630 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20813920 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
38228630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

piezo-type mechanosensitive ion channel component 1

  • family with sequence similarity 38, member A

  • protein PIEZO1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18723 Yoda 1 99.97% Unkown
HY-P1410 GsMTx4 Inhibitor 99.89% Unkown
HY-126010 Dooku1 Antagonist 99.90% Unkown
HY-P1410A GsMTx4 TFA Inhibitor 99.85% Unkown
HY-131018 Jedi2 99.93% Unkown
HY-162501 Yaddle1 Agonist 99.98% Unkown
HY-175416 Yoda2 Agonist 99.57% Unkown
HY-RS10483 PIEZO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-165607S MCB-22-174 99.78% Unkown
HY-RS17433 Piezo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181467 KC159 Agonist 99.9% Unkown
HY-169332 Piezo1 agonist 1-d2 / Unkown
HY-RS23888 Piezo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181743 Piezo1 agonist 2 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Piezo1 NCBI NCBI:9780