Slc13a5 - solute carrier family 13 (sodium-dependent citrate transporter), member 5 Gene

Also Known as Indy; Nact; mINDY; NaC2/NaCT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237831

Summary

Enables citrate transmembrane transporter activity; organic acid:sodium symporter activity; and succinate transmembrane transporter activity. Involved in carboxylic acid transport and cellular response to lithium ion. Acts upstream of or within succinate transport and tricarboxylic acid transport. Predicted to be located in basolateral plasma membrane; cytosol; and nucleoplasm. Predicted to be integral component of membrane. Is expressed in forelimb and humerus cartilage condensation. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to human SLC13A5 (solute carrier family 13 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc13a5 Products (3)

mRNA Protein Name
NM_001004148.5 NP_001004148.1 Na(+)/citrate cotransporter isoform 1
NM_001372402.1 NP_001359331.1 Na(+)/citrate cotransporter isoform 2
NM_001372403.1 NP_001359332.1 Na(+)/citrate cotransporter isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables citrate transmembrane transporter activity IDA
IDA: Inferred from direct assay
14656221 MGI
enables organic acid:sodium symporter activity IDA
IDA: Inferred from direct assay
26324167 MGI
enables succinate transmembrane transporter activity IDA
IDA: Inferred from direct assay
14656221 MGI
enables tricarboxylic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
14656221 MGI
Biological Process GO Annotation Evidence References Source
involved in alpha-ketoglutarate transport IDA
IDA: Inferred from direct assay
26324167 MGI
involved in cellular response to lithium ion IDA
IDA: Inferred from direct assay
26324167 MGI
acts upstream of or within citrate transport IDA
IDA: Inferred from direct assay
14656221 MGI
involved in citrate transport IDA
IDA: Inferred from direct assay
26324167 MGI
involved in citrate transport IMP
IMP: Inferred from mutant phenotype
32682952 MGI
involved in fumarate transport IDA
IDA: Inferred from direct assay
26324167 MGI
involved in oxaloacetate transport IDA
IDA: Inferred from direct assay
26324167 MGI
acts upstream of or within succinate transport IDA
IDA: Inferred from direct assay
14656221 MGI
involved in succinate transport IDA
IDA: Inferred from direct assay
26324167 MGI
acts upstream of or within tricarboxylic acid transport IDA
IDA: Inferred from direct assay
14656221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/citrate cotransporter

solute carrier family 13 member 5

  • novel solute carrier family 13 (sodium-dependent dicarboxylate transporter) (Slc13a2 or 3) member

  • sodium-coupled citrate transporter

  • sodium-dependent citrate transporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125990 SLC13A5-IN-1 Inhibitor 98.62% Unkown
HY-120669 PF-06761281 Inhibitor 99.52% Unkown
HY-120103 PF-06649298 Inhibitor 98.32% Unkown
HY-124738 BI 01383298 Inhibitor 99.44% Unkown
HY-RS13009 SLC13A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158160 LBA-3 Inhibitor / Unkown
HY-RS18581 Slc13a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25066 Slc13a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc13a5 NCBI NCBI:284111