Lrrc8a - leucine rich repeat containing 8A VRAC subunit A Gene

Also Known as ebo; Lrrc8; SWELL1; mKIAA1437

Species: Mus musculus

Gene Type: protein coding
Gene ID: 241296

Summary

Predicted to enable cyclic-GMP-AMP transmembrane transporter activity; identical protein binding activity; and volume-sensitive anion channel activity. Predicted to contribute to anion channel activity. Predicted to be involved in several processes, including anion transport; cell volume homeostasis; and protein hexamerization. Predicted to act upstream of or within cell differentiation; ion transport; and spermatogenesis. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of lysosomal membrane and integral component of plasma membrane. Predicted to be part of ion channel complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc8a Products (1)

mRNA Protein Name
NM_177725.4 NP_808393.1 volume-regulated anion channel subunit LRRC8A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclic-GMP-AMP transmembrane transporter activity IDA
IDA: Inferred from direct assay
32277911 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
29769723 MGI
enables volume-sensitive anion channel activity IDA
IDA: Inferred from direct assay
29769723 MGI
enables volume-sensitive anion channel activity IMP
IMP: Inferred from mutant phenotype
29773801 MGI
Biological Process GO Annotation Evidence References Source
involved in cyclic-GMP-AMP transmembrane import across plasma membrane IDA
IDA: Inferred from direct assay
32277911 MGI
involved in intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
29773801 MGI
involved in monoatomic anion transmembrane transport IDA
IDA: Inferred from direct assay
29769723 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
29773801 MGI
involved in positive regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
31387946 MGI
involved in pre-B cell differentiation IMP
IMP: Inferred from mutant phenotype
14660746 MGI
involved in protein hexamerization IDA
IDA: Inferred from direct assay
29769723 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
30135305 MGI
Cellular Component GO Annotation Evidence References Source
part of monoatomic ion channel complex IDA
IDA: Inferred from direct assay
29769723 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29769723 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

volume-regulated anion channel subunit LRRC8A

  • leucine-rich repeat-containing 8

  • leucine-rich repeat-containing protein 8A

  • protein ebouriffe

Lrrc8a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lrrc8a Q80WG5 Lrrc8a Mus musculus Q80WG5
3D-EM
30775971
Intra
Lrrc8a Q80WG5 Lrrc8a Mus musculus Q80WG5
GMS
29769723
Intra
Lrrc8a Q80WG5 Lrrc8a Mus musculus Q80WG5
SLS
29769723
Intra
Lrrc8a Q80WG5 Lrrc8a Mus musculus Q80WG5
3D-EM
29769723
Intra
Lrrc8a Q80WG5 Lrrc8c Mus musculus Q8R502
3D-EM
29769723
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173189 2-5A Inhibitor / Unkown
HY-RS07827 LRRC8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21148 Lrrc8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27665 Lrrc8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrc8a NCBI NCBI:56262