Atp1a1 - ATPase Na+/K+ transporting subunit alpha 1 Gene

Also Known as Nkaa1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24211

Summary

Enables several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; inorganic cation transmembrane transport; and membrane hyperpolarization. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a1 Products (1)

mRNA Protein Name
NM_012504.1 NP_036636.1 sodium/potassium-transporting ATPase subunit alpha-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
12730684 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
12730684 RGD
enables P-type sodium:potassium-exchanging transporter activity IDA
IDA: Inferred from direct assay
12531906 RGD
enables ankyrin binding IPI
IPI: Inferred from physical interaction
8159688 RGD
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
17728397 RGD
enables potassium ion binding IDA
IDA: Inferred from direct assay
16269407 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12093728 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16269407 RGD
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
28787093 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17939993 RGD
enables protein-folding chaperone binding IDA
IDA: Inferred from direct assay
18768923 RGD
enables sodium ion binding IDA
IDA: Inferred from direct assay
16269407 RGD
enables sodium ion binding IMP
IMP: Inferred from mutant phenotype
18075585 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
17458903 RGD
involved in membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
17001300 RGD
involved in potassium ion import across plasma membrane IDA
IDA: Inferred from direct assay
12531906 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
12093728 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
15629895 RGD
involved in regulation of sodium ion transport IDA
IDA: Inferred from direct assay
17939993 RGD
involved in sodium ion export across plasma membrane IDA
IDA: Inferred from direct assay
18075585 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
12093728 RGD
involved in transmembrane transport IDA
IDA: Inferred from direct assay
18075585 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
18768923 RGD
located in T-tubule IDA
IDA: Inferred from direct assay
17442282 RGD
located in basolateral plasma membrane IMP
IMP: Inferred from mutant phenotype
16914892 RGD
located in caveola IDA
IDA: Inferred from direct assay
16624992 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18768923 RGD
located in endosome IDA
IDA: Inferred from direct assay
16893515 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
17442282 RGD
located in membrane IDA
IDA: Inferred from direct assay
28787093 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18768923 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
17442282 RGD
part of sodium:potassium-exchanging ATPase complex IDA
IDA: Inferred from direct assay
12093728 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/potassium-transporting ATPase subunit alpha-1

  • ATPase, Na+/K+ transporting, alpha 1 polypeptide

  • ATPase, Na+K+ transporting, alpha 1

  • Na(+)/K(+) ATPase alpha-1 subunit

  • sodium pump subunit alpha-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-Y0344D Sodium chloride, for cell culture Activator 99.9% Phase 4
HY-12283 Rostafuroxin 98.02% Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2414 Periplogenin ≥99.70% Unkown
HY-P2657 Verucopeptin Inhibitor 97.0% Unkown
HY-Y0344J Sodium chloride, for molecular biology 99.97% Unkown
HY-P1565A Transdermal Peptide Disulfide TFA Inhibitor 99.95% Unkown
HY-Y0344I Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al 99.99% Unkown
HY-RS01182 ATP1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P1565 Transdermal Peptide Disulfide Inhibitor 98.79% Unkown
HY-RS16918 Atp1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01184 ATP1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01185 ATP1A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01186 ATP1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Y0344H Sodium chloride, United States Pharmacopeia (USP) Reference Standard / Unkown
HY-RS21097 Atp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23361 Atp1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27615 Atp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp1a1 NCBI NCBI:476