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ABCC1 - Abcc1 ATP binding cassette subfamily C member 1 Gene

Also Known as Mrp; Mrp1; Abcc1a; Avcc1a

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24565

Summary

Enables several functions, including ATPase-coupled transmembrane transporter activity; glutathione transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including glutathione transmembrane transport; lipid transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basolateral plasma membrane and cytoplasm. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]

ABCC1 Products (1)

mRNA	Protein	Name
NM_022281.2	NP_071617.2	multidrug resistance-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type xenobiotic transporter activity	IDA IDA: Inferred from direct assay	12867490	RGD
enables ABC-type xenobiotic transporter activity	IMP IMP: Inferred from mutant phenotype	12893836	RGD
enables ATPase-coupled lipid transmembrane transporter activity	IDA IDA: Inferred from direct assay	12867490	RGD
enables amide transmembrane transporter activity	IDA IDA: Inferred from direct assay	12423064	RGD
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	12423064	RGD
enables glutathione transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	12125073	RGD
enables long-chain fatty acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	12867490	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17141959	RGD
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	17050692	RGD
involved in export across plasma membrane	IDA IDA: Inferred from direct assay	15198509	RGD
involved in glial cell differentiation	IMP IMP: Inferred from mutant phenotype	17141959	RGD
involved in glutathione transmembrane transport	IMP IMP: Inferred from mutant phenotype	12125073	RGD
involved in long-chain fatty acid import across plasma membrane	IDA IDA: Inferred from direct assay	12867490	RGD
involved in phospholipid efflux	IMP IMP: Inferred from mutant phenotype	17050692	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17050692	RGD
involved in regulation of cellular response to drug	IDA IDA: Inferred from direct assay	15198509	RGD
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	11208926	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	14641820	RGD
involved in transmembrane transport	IDA IDA: Inferred from direct assay	12423064	RGD
involved in transmembrane transport	IMP IMP: Inferred from mutant phenotype	17854063	RGD
involved in xenobiotic detoxification by transmembrane export across the plasma membrane	IDA IDA: Inferred from direct assay	12423064	RGD
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	12893836	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	18619525	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11804835	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
multidrug resistance-associated protein 1	ATP-binding cassette sub-family C ( CFTR/MRP) member 1a ATP-binding cassette sub-family C member 1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ATP-binding cassette, sub-family C, member 1-like ATP-binding cassette, subfamily C (CFTR/MRP),

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-N0488A	Vincristine	98.60%	Yes
HY-B1794	Thiethylperazine	99.91%	Unkown
HY-B1794A	Thiethylperazine dimaleate	99.99%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17013A	Dofequidar fumarate	Inhibitor	98.0%	Phase 3

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19989	MK-571		98.85%	Unkown
HY-19989A	MK-571 sodium		99.75%	Unkown
HY-101453	Ceefourin 1	Inhibitor	99.72%	Unkown
HY-N3610	Coclaurine	Antagonist	98.97%	Unkown
HY-17013	Dofequidar	Inhibitor	99.29%	Unkown
HY-113805	MC70	Inhibitor	99.50%	Unkown
HY-136907	(S)-Verapamil		/	Unkown
HY-173189	2-5A	Inhibitor	/	Unkown
HY-RS23355	Abcc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-146676	UR-MB108	Inhibitor	/	Unkown
HY-17013D	Dofequidar sesquifumarate	Inhibitor	/	Unkown
HY-17648	MBL-II-141	Inhibitor	/	Unkown
HY-182253	WS-691	Modulator	/	Unkown
HY-A0188	Norzine dimalate		/	Unkown
HY-D1609	BODIPY FL Verapamil hydrochloride		/	Unkown
HY-RS00057	ABCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B1794S	Thiethylperazine-d3		/	Unkown
HY-RS16913	Abcc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ABCC1	NCBI	NCBI:4363