Muc1 - mucin 1, cell surface associated Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24571

Summary

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to retinoic acid; female pregnancy; and response to hypoxia. Located in apical plasma membrane and cytoplasm. Used to study allergic rhinitis. Biomarker of allergic rhinitis; cholangiocarcinoma; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic Cancer (multiple). Orthologous to human MUC1 (Mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]

Muc1 Products (1)

mRNA Protein Name
NM_001398538.1 NP_001385467.1 mucin-1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
8967520 RGD
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
8967520 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
13677617 RGD
involved in in utero embryonic development IEP
IEP: Inferred from expression pattern
21263748 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19549898 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19549898 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-1

  • Mucin1

  • mucin 1, transmembrane

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1203 Fludrocortisone 98.99% Yes
HY-B1203R Fludrocortisone (Standard) / Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99591 Sontuzumab Inhibitor 99.66% Phase 2
HY-P99634 Gatipotuzumab 99.204% Phase 1
HY-P991317 BTH1704 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1925A GO-203 TFA 98.39% Unkown
HY-177442 DS-3939a 99.15% Unkown
HY-P2508 MUC1, mucin core 98.84% Unkown
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / Unkown
HY-W115607 PEG4000-bis-amine 99.96% Unkown
HY-136453A CR-1-30-B Control 99.92% Unkown
HY-158469 Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled 98.91% Unkown
HY-160062 S2.2 aptamer sodium Chemical 92.06% Unkown
HY-P1925B L-GO-203 TFA Inhibitor 98.69% Unkown
HY-RS08831 MUC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160060 MA3 aptamer sodium Chemical 95.74% Unkown
HY-B1203S Fludrocortisone-d5 / Unkown
HY-158467 Core 1 O-glycan (C1), 2AB labelled / Unkown
HY-158471 Core 1 O-glycan (C1) / Unkown
HY-B1203S1 Fludrocortisone-d2 / Unkown
HY-P10701 Q11 peptide / Unkown
HY-P5472 Tumour-associated MUC1 epitope / Unkown
HY-182441 (-)-AGN 192403 hydrochloride / Unkown
HY-RS16863 Muc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23304 Muc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99968 Clivatuzumab Inhibitor ≥99.0% Unkown
HY-P990831 Anti-MUC1/CD227 Antibody (C595 (NCRC48)) Inhibitor 95.00% Unkown
HY-P991608 CTM01 Inhibitor / Unkown
HY-P992091 Nacolomab Inhibitor / Unkown
HY-P992131 Sacomitatug Inhibitor 99.90% Unkown
HY-P992096 Pemtumomab Antibody Inhibitor / Unkown
HY-P992374 huDMB5F3 Inhibitor / Unkown
HY-P991318 AR20.5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Muc1 NCBI NCBI:4582
Macaca fascicularis Muc1 NCBI NCBI:102123068
Mus musculus Muc1 NCBI NCBI:17829