Vamp2 - vesicle-associated membrane protein 2 Gene

Also Known as SYB; Syb2; RATVAMPB; RATVAMPIR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24803

Summary

Enables several functions, including protein C-terminus binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; exocytosis; and regulation of delayed rectifier Potassium Channel activity. Located in neuron projection terminus; plasma membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is integral component of synaptic vesicle membrane. Orthologous to human VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vamp2 Products (1)

mRNA Protein Name
NM_012663.2 NP_036795.1 vesicle-associated membrane protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
7553862 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
9671503 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
12526776 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
21856303 RGD
enables lipid binding EXP
EXP: Inferred from Experiment
19918058 RGD
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
19918058 RGD
enables myosin binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8567678 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8567678 RGD
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
7553862 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
19077057 RGD
Biological Process GO Annotation Evidence References Source
involved in SNARE complex assembly IMP
IMP: Inferred from mutant phenotype
9671503 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
10051443 RGD
involved in regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
19690160 RGD
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
11245593 RGD
involved in regulation of synaptic vesicle recycling IMP
IMP: Inferred from mutant phenotype
21808019 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
15537656 RGD
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
1331807 RGD
involved in synaptic vesicle exocytosis IEP
IEP: Inferred from expression pattern
1331807 RGD
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
1331807 RGD
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
11245593 RGD
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
10051443 RGD
located in neuron projection terminus IDA
IDA: Inferred from direct assay
10908612 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15537656 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
26488171 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
26488171 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15537656 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
10908612 RGD
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
17110340 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
17110340 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23792689 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IMP
IMP: Inferred from mutant phenotype
9671503 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
IDA: Inferred from direct assay
19132534 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
19077057 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 2

  • Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2)

  • VAMP-2

  • Vesicle-associated membrane protein (synaptobrevin 2)

  • synaptobrevin-2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5366 PEP1 Modulator 99.88% Unkown
HY-RS15594 VAMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21080 Vamp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27597 Vamp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp2 NCBI NCBI:6844