Ugt1a1 - UDP glucuronosyltransferase family 1 member A1 Gene

Also Known as Ugt1; Udpgt; UDPGT 1-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24861

Summary

Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and cellular response to lipid. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ Cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Ugt1a1 Products (1)

mRNA Protein Name
NM_012683.2 NP_036815.1 UDP-glucuronosyltransferase 1A1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IDA
IDA: Inferred from direct assay
17965520 RGD
enables glucuronosyltransferase activity IDA
IDA: Inferred from direct assay
11829457 RGD
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
9737578 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16222444 RGD
involved in biphenyl catabolic process IDA
IDA: Inferred from direct assay
16006569 RGD
involved in cellular glucuronidation IDA
IDA: Inferred from direct assay
9224784 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
9327435 RGD
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
11412396 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
10100302 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
10100302 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
8632018 RGD
involved in flavonoid glucuronidation IDA
IDA: Inferred from direct assay
8806713 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
16310220 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11848303 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
11829457 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19356101 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
11299074 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11854140 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
9841869 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
11086234 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11829457 RGD
involved in xenobiotic glucuronidation IDA
IDA: Inferred from direct assay
8806713 RGD
Cellular Component GO Annotation Evidence References Source
part of cytochrome complex IDA
IDA: Inferred from direct assay
17965520 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14561759 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

UDP-glucuronosyltransferase 1A1

  • B1

  • UDP glucuronosyltransferase 1 family, polypeptide A1

  • UDP glycosyltransferase 1 family, polypeptide A1

  • UDP-glucuronosyltransferase 1 family member 1

  • UDP-glucuronosyltransferase 1-1

  • UGT1*1

  • UGT1-01

  • UGT1.1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15592 Cabotegravir Inhibitor 99.92% Unkown
HY-15592A Cabotegravir sodium Inhibitor 99.87% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0372 Licochalcone A Inducer 99.76% Phase 1
HY-124364 RO6889678 / Phase 1

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111832 1,2,3,6-Tetragalloylglucose Inhibitor 99.08% Unkown
HY-N0762 Isobavachin 99.88% Unkown
HY-107850 Pregnanediol Inhibitor 99.97% Unkown
HY-160250 UGT1A1-IN-1 Inhibitor 99.27% Unkown
HY-111539 BAY-1316957 Antagonist 99.73% Unkown
HY-130046 16-Epiestriol Inhibitor 99.04% Unkown
HY-135581 Raloxifene 6-glucuronide Modulator 96.14% Unkown
HY-N4267 Yangambin 98.27% Unkown
HY-100319 UK-157147 Inhibitor / Unkown
HY-122163 MK-3901 / Unkown
HY-135581S1 Raloxifene 6-glucuronide-d4 lithium Modulator / Unkown
HY-15592S4 Cabotegravir-d6 Inhibitor / Unkown
HY-170503 MAT2A-IN-20 Inhibitor / Unkown
HY-179622 ZS34 / Unkown
HY-E72105 Human UGT1A1 / Unkown
HY-E72107 Human UGT1A4 / Unkown
HY-N0372R Licochalcone A (Standard) Inducer / Unkown
HY-N19800 Anhydroicaritin-3,7-di-O-glucuronide / Unkown
HY-RS15426 UGT1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15427 UGT1A10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15429 UGT1A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15430 UGT1A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15431 UGT1A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15432 UGT1A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16797 Ugt1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23238 Ugt1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W739842 8-Hydroxywarfarin Inhibitor 95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ugt1a1 NCBI NCBI:54658