Eln - elastin Gene

Also Known as Trela; TREL11; Trela26; RATTREL11

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25043

Summary

Enables extracellular matrix constituent conferring elasticity. Involved in several processes, including cellular response to L-ascorbic acid; cellular response to growth factor stimulus; and cellular response to lipid. Located in extracellular matrix and extracellular space. Used to study abdominal aortic aneurysm. Biomarker of autosomal recessive polycystic kidney disease; bladder neck obstruction; congenital diaphragmatic hernia; liver cirrhosis; and silicosis. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin). [provided by Alliance of Genome Resources, Apr 2022]

Eln Products (1)

mRNA Protein Name
NM_012722.1 NP_036854.1 elastin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix constituent conferring elasticity IMP
IMP: Inferred from mutant phenotype
10090127 RGD
Biological Process GO Annotation Evidence References Source
involved in aorta development IEP
IEP: Inferred from expression pattern
18803461 RGD
involved in blood vessel remodeling IDA
IDA: Inferred from direct assay
12844513 RGD
involved in cellular response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
2859894 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
18847363 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
2235137 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
11967999 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
16055482 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
8997264 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
8238530 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
9224206 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
9609733 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18279932 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
16473861 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
8238530 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

elastin

  • Tropoelastin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50882 ELN318463 Inhibitor 99.45% Unkown
HY-15043 ELN-441958 Antagonist 99.17% Unkown
HY-115038 ELN484228 Antagonist 99.86% Unkown
HY-RS04316 ELN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-50882A ELN318463 racemate Inhibitor / Unkown
HY-RS20236 Eln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26743 Eln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eln NCBI NCBI:2006