FUT7 - fucosyltransferase 7 Gene

Also Known as FucT-VII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2529

About FUT7

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,030,174-137,032,088 (from NCBI)

This gene has 1 transcript (splice variant), 285 orthologues and 7 paralogues. Biased expression in lymph node (RPKM 1.7), spleen (RPKM 1.5) and 12 other tissues.

Summary

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]

FUT7 Products (1)

mRNA	Protein	Name
NM_004479.4	NP_004470.1	alpha-(1,3)-fucosyltransferase 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	9473504	GOA
enables alpha-(1->3)-fucosyltransferase activity	IDA IDA: Inferred from direct assay	8207002	GOA
enables alpha-(1->3)-fucosyltransferase activity	IMP IMP: Inferred from mutant phenotype	15926890	GOA
enables fucosyltransferase activity	IDA IDA: Inferred from direct assay	9299472	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	9299472	GOA
involved in embryo implantation	IMP IMP: Inferred from mutant phenotype	18402946	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	10386892	GOA
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18553500	GOA
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	29138114	GOA
involved in protein glycosylation	IDA IDA: Inferred from direct assay	11404359	GOA
involved in regulation of cell adhesion molecule production	IMP IMP: Inferred from mutant phenotype	8666674	GOA
involved in regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	10200296	GOA
involved in regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17229154	GOA
involved in regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	23192350	GOA
involved in regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	23192350	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in trans-Golgi network	IDA IDA: Inferred from direct assay	23192350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT7 Protein Structure

Glyco_transf_10

0
100
200
300
342 a.a.

Protein Preferred Names	Protein Names
alpha-(1,3)-fucosyltransferase 7	fuc-TVII

FUT7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FUT7	Q11130	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ehrlichiosis	Human Ehrlichiosis He Hey
Human Granulocytic Anaplasmosis	Human Granulocytic Ehrlichiosis Hge Human Ehrlichial Infection, Human Granulocytic Type Human Anaplasmosis Due To Anaplasma Phagocytophilum
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70156	Fucosyltransferase 7		/	Unkown
HY-RS05158	FUT7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18933	Fut7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25423	Fut7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FUT7	VGNC	VGNC:41014
Macaca mulatta	FUT7	VGNC	VGNC:103267
Rattus norvegicus	FUT7	RGD	RGD:735019
Felis catus	FUT7	VGNC	VGNC:102931
Bos taurus	FUT7	VGNC	VGNC:29151
Mus musculus	FUT7	MGD	MGI:107692
Others	FUT7	NCBI