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Aqp4 - aquaporin 4 Gene

Also Known as Miwc; WCH4; AQP-4

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25293

Summary

This gene encodes a member of the Aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant Aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

Aqp4 Products (5)

mRNA	Protein	Name
NM_001142366.2	NP_001135838.1	aquaporin-4 isoform M23
NM_001270558.2	NP_001257487.1	aquaporin-4 isoform 3
NM_001270559.2	NP_001257488.1	aquaporin-4 isoform 4
NM_001317749.1	NP_001304678.1	aquaporin-4 isoform M1x
NM_012825.4	NP_036957.1	aquaporin-4 isoform M1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16650285	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21262839	RGD
enables water channel activity	IDA IDA: Inferred from direct assay	7528931	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in carbon dioxide transport	IDA IDA: Inferred from direct assay	19273840	RGD
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16325200	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	21471464	RGD
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	22449442	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	22449442	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	22449442	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	18579859	RGD
involved in intracellular water homeostasis	IDA IDA: Inferred from direct assay	21251984	RGD
involved in negative regulation of cell adhesion molecule production	IMP IMP: Inferred from mutant phenotype	22449442	RGD
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	22449442	RGD
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22449442	RGD
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	16325200	RGD
involved in regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	22449442	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	21724913	RGD
involved in water transport	IDA IDA: Inferred from direct assay	7528931	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	20849844	RGD
located in astrocyte end-foot	IDA IDA: Inferred from direct assay	29055082	RGD
located in basal plasma membrane	IDA IDA: Inferred from direct assay	9875338	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9875338	RGD
located in cell projection membrane	IDA IDA: Inferred from direct assay	9875338	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16325200	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20153404	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	20849844	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
aquaporin-4	mercurial-insensitive water channel

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115460	AER-271		96.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W008574	TGN-020		99.97%	Unkown
HY-W008574A	TGN-020 sodium		99.96%	Unkown
HY-W176557	TGN-073		99.53%	Unkown
HY-P10936A	AQP4 (201-220) TFA		99.91%	Unkown
HY-N10756	Hyp9	Agonist	99.90%	Unkown
HY-N4246	Bacopaside I		99.20%	Unkown
HY-157226	ORI-TRN-002	Inhibitor	98.13%	Unkown
HY-RS00876	AQP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W017091	3-Phenoxy-1,2-propanediol	Inhibitor	95.0%	Unkown
HY-18805	Nicotinanilide	Inhibitor	99.84%	Unkown
HY-P10936	AQP4 (201-220)		/	Unkown
HY-P10937	AQP4 (205-215)		/	Unkown
HY-P10937A	AQP4 (205-215) TFA		/	Unkown
HY-RS16702	Aqp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23136	Aqp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991869	Aquaporumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aqp4	NCBI	NCBI:361