Fnta - farnesyltransferase, CAAX box, alpha Gene

Also Known as PFAS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25318

Summary

Contributes to several functions, including peptide binding activity; Protein Prenyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell population proliferation; and regulation of nitric-oxide synthase biosynthetic process. Located in cytoplasm. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human FNTA (farnesyltransferase, CAAX box, alpha). [provided by Alliance of Genome Resources, Apr 2022]

Fnta Products (1)

mRNA Protein Name
NM_012847.2 NP_036979.2 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to CAAX-protein geranylgeranyltransferase activity IDA
IDA: Inferred from direct assay
8089111 RGD
contributes to heterocyclic compound binding IDA
IDA: Inferred from direct assay
15248757 RGD
contributes to peptide binding IDA
IDA: Inferred from direct assay
9705207 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9065406 RGD
contributes to protein farnesyltransferase activity IDA
IDA: Inferred from direct assay
8089111 RGD
enables protein farnesyltransferase activity IDA
IDA: Inferred from direct assay
1763049 RGD
contributes to small molecule binding IDA
IDA: Inferred from direct assay
15248757 RGD
contributes to zinc ion binding IDA
IDA: Inferred from direct assay
15248757 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11313965 RGD
involved in negative regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
9153192 RGD
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
10544242 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10544242 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
9153192 RGD
involved in response to cytokine IMP
IMP: Inferred from mutant phenotype
9153192 RGD
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
16257390 RGD
Cellular Component GO Annotation Evidence References Source
part of CAAX-protein geranylgeranyltransferase complex IDA
IDA: Inferred from direct assay
15248757 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

  • CAAX farnesyltransferase subunit alpha

  • FTase-alpha

  • Farnesyltransferase, subunit alpha

  • GGTase-I-alpha

  • ras proteins prenyltransferase subunit alpha

  • type I protein geranyl-geranyltransferase subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05025 FNTA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22173 Fnta Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28695 Fnta Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fnta NCBI NCBI:2339