FNTA - farnesyltransferase, CAAX box, alpha Gene

Also Known as FPTA; PTAR2; PGGT1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2339

About FNTA

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:43,056,323-43,085,785 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 32.7), placenta (RPKM 27.4) and 25 other tissues.

Summary

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

FNTA Products (1)

mRNA	Protein	Name
NM_002027.3	NP_002018.1	protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

FNTA Protein Structure

PPTA

0
100
200
300
379 a.a.

Protein Preferred Names	Protein Names
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	FTase-alpha

FNTA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FNTA	P49354	AP4M1	Homo sapiens	O00189	Y2H Prey Pooling	32296183
Intra	FNTA	P49354	AP4M1	Homo sapiens	O00189	Y2H Array	32296183
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	Anti Tag CoIP	33961781
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	Complementation	32296183
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	Validated Y2H	32296183
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	X-Ray Diffraction	15451670
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	Y2H Prey Pooling	32296183
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	Y2H Array	32296183
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	X-Ray Diffraction	12036349
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	X-Ray Diffraction	15248757
Intra	FNTA	P49354	FNTB	Homo sapiens	P49356	X-Ray Diffraction	11687658
Intra	FNTA	P49354	PGGT1B	Homo sapiens	P53609	Validated Y2H	32296183
Intra	FNTA	P49354	PGGT1B	Homo sapiens	P53609	Anti Tag CoIP	33961781
Intra	FNTA	P49354	PGGT1B	Homo sapiens	P53609	TAP	24981860
Intra	FNTA	P49354	PGGT1B	Homo sapiens	P53609	Y2H Array	32296183
Intra	FNTA	P49354	PGGT1B	Homo sapiens	P53609	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FNTA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83096	FNTA Antibody (YA2841)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
HY-P83096A	FNTA Antibody (YA2841)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat

Related Diseases

Diseases	Alias
Dystonia 6, Torsion	DYT6 Torsion Dystonia 6 Dystonia 6 Idiopathic Torsion Dystonia Of Mixed Type Primary Dystonia, Dyt6 Type Torsion Dystonia, Adult-Onset, Mixed Type Dyt-Thap1 Adolescent-Onset Dystonia Of Mixed Type Torsion Dystonia Adult Onset Mixed Type Dyt6 Dystonia Thap1 Dystonia Generalized Cervical And Upper-Limb-Onset Dystonia Adult-Onset Torsion Dystonia Mixed Type Autosomal Dominant Torsion Dystonia 6 Dystonia-6 Torsion Dystonia Type 6 Dystonia, Type 6, Torsion
Non-Functioning Pancreatic Endocrine Tumor	Non Functioning Pancreatic Endocrine Tumor Non-Functioning Epts Non-Functioning Endocrine Pancreatic Tumors

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05025	FNTA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22173	Fnta Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28695	Fnta Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FNTA	VGNC	VGNC:40937
Mus musculus	FNTA	MGD	MGI:104683
Felis catus	FNTA	VGNC	VGNC:62327
Bos taurus	FNTA	VGNC	VGNC:29070
Rattus norvegicus	FNTA	RGD	RGD:2625
Others	FNTA	NCBI