2. Gene
  3. Dbh - dopamine beta-hydroxylase Gene

Dbh - dopamine beta-hydroxylase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as DOPBHY

Gene ID: 25699 | Gene type: protein coding

About Dbh

Primary_assembly 3: 10,488,260-10,505,248 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 200 orthologues, 2 paralogues and is associated with 22 phenotypes. Restricted expression toward (RPKM 642.7).

Summary

Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular biogenic amine metabolic process; cellular response to manganese ion; and cellular response to nicotine. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; hypertension; mental depression; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Dbh Products(1)

mRNA Protein Name
NM_013158.3 NP_037290.3 dopamine beta-hydroxylase

Dbh Protein Structure

DOMON

DOMON: pfam03351 (59 - 174)

Cu2_monooxygen

Cu2_monooxygen: pfam01082 (216 - 339)

Cu2_monoox_C

Cu2_monoox_C: pfam03712 (362 - 518)

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  • 621 a.a.
Protein Preferred Names Protein Names

dopamine beta-hydroxylase

Dopamine beta hydroxylase (dopamine beta-monooxygenase)

dopamine beta-monooxygenase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106004 Zamicastat Inhibitor ≥98.0% Phase 2
HY-14838 Etamicastat Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N7204 4-Hydroxyderricin Inhibitor 99.97% Unkown
HY-14838A Etamicastat hydrochloride Inhibitor 98.14% Unkown
HY-RS03544 DBH Human Pre-designed siRNA Set A / Unkown
HY-RS03545 Dbh Mouse Pre-designed siRNA Set A / Unkown
HY-RS03546 Dbh Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dbh NCBI NCBI:1621