Dbh - dopamine beta-hydroxylase Gene

Also Known as DOPBHY

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25699

About Dbh

Primary_assembly 3: 10,488,260-10,505,248 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 200 orthologues, 2 paralogues and is associated with 22 phenotypes. Restricted expression toward (RPKM 642.7).

Summary

Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular biogenic amine metabolic process; cellular response to manganese ion; and cellular response to nicotine. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; hypertension; mental depression; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Dbh Products (1)

mRNA Protein Name
NM_013158.3 NP_037290.3 dopamine beta-hydroxylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IMP
IMP: Inferred from mutant phenotype
10573542 RGD
enables dopamine beta-monooxygenase activity IDA
IDA: Inferred from direct assay
15380000 RGD
enables dopamine beta-monooxygenase activity IMP
IMP: Inferred from mutant phenotype
11521740 RGD
Biological Process GO Annotation Evidence References Source
involved in bone development IEP
IEP: Inferred from expression pattern
20090303 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
19276553 RGD
involved in cellular response to nicotine IEP
IEP: Inferred from expression pattern
20827341 RGD
involved in norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10573542 RGD
involved in octopamine metabolic process IMP
IMP: Inferred from mutant phenotype
11521740 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
19079842 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
11914591 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16713504 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
19893991 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
18363828 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
19893991 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18783367 RGD
involved in response to ozone IEP
IEP: Inferred from expression pattern
19356678 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18522866 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20626387 RGD
involved in social behavior IEP
IEP: Inferred from expression pattern
15345906 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
20478367 RGD
located in axon IDA
IDA: Inferred from direct assay
15380000 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17572158 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18440151 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
19651110 RGD
located in varicosity IDA
IDA: Inferred from direct assay
19651110 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dbh Protein Structure

DOMON

DOMON: pfam03351 (59 - 174)

Cu2_monooxygen

Cu2_monooxygen: pfam01082 (216 - 339)

Cu2_monoox_C

Cu2_monoox_C: pfam03712 (362 - 518)

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  • 500
  • 621 a.a.
Protein Preferred Names Protein Names

dopamine beta-hydroxylase

  • Dopamine beta hydroxylase (dopamine beta-monooxygenase)

  • dopamine beta-monooxygenase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-106004 Zamicastat Inhibitor 99.93% Phase 2
HY-14838 Etamicastat Inhibitor / Phase 2
HY-14838A Etamicastat hydrochloride Inhibitor 98.14% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7204 4-Hydroxyderricin 99.79% Unkown
HY-RS03544 DBH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156989 Butobendine Inhibitor / Unkown
HY-RS03545 Dbh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03546 Dbh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dbh NCBI NCBI:1621