ZNF683 - zinc finger protein 683 Gene

Also Known as Hobit

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 257101

About ZNF683

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,361,634-26,374,518 (from NCBI)

This gene has 9 transcripts (splice variants), 56 orthologues and 28 paralogues. Biased expression in testis (RPKM 20.6), salivary gland (RPKM 1.7) and 1 other tissue.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in T cell receptor signaling pathway; cellular response to ionomycin; and regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF683 Products (3)

mRNA Protein Name
NM_001114759.3 NP_001108231.1 tissue-resident T-cell transcription regulator protein ZNF683 isoform 1
NM_001307925.1 NP_001294854.1 tissue-resident T-cell transcription regulator protein ZNF683 isoform 2
NM_173574.3 NP_775845.2 tissue-resident T-cell transcription regulator protein ZNF683 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26179882 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
26179882 GOA
involved in cellular response to ionomycin IDA
IDA: Inferred from direct assay
26179882 GOA
NOT involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26179882 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26179882 GOA
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
26179882 GOA
NOT involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
26179882 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
26179882 GOA
NOT involved in regulation of type II interferon production IDA
IDA: Inferred from direct assay
26179882 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF683 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (336 - 360)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (412 - 436)

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  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

tissue-resident T-cell transcription regulator protein ZNF683

  • homolog of Blimp-1 in T cells

ZNF683 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF683 Q8IZ20 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
ZNF683 Q8IZ20 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
ZNF683 Q8IZ20 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Intra
ZNF683 Q8IZ20 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra
ZNF683 Q8IZ20 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ZNF683 Q8IZ20 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16164 ZNF683 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZNF683 VGNC VGNC:80414
Bos taurus ZNF683 VGNC VGNC:37327
Canis familiaris ZNF683 VGNC VGNC:48794
Mus musculus ZNF683 MGD MGI:3650254
Macaca mulatta ZNF683 VGNC VGNC:79718
Rattus norvegicus ZNF683 RGD RGD:2323855
Others ZNF683 NCBI