Ccne1 - cyclin E1 Gene

Also Known as Ccne; CYCLE

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25729

Summary

Enables protein kinase binding activity. Involved in several processes, including animal organ development; response to nutrient; and response to steroid hormone. Located in centrosome; cytoplasm; and nucleus. Biomarker of hepatocellular carcinoma; hypertension; and ovarian carcinoma. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Apr 2022]

Ccne1 Products (1)

mRNA Protein Name
NM_001100821.1 NP_001094291.1 G1/S-specific cyclin-E1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18356301 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15809057 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10952244 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16273211 RGD
involved in antral ovarian follicle growth IEP
IEP: Inferred from expression pattern
17084963 RGD
involved in cellular response to nutrient IEP
IEP: Inferred from expression pattern
17979132 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
15809057 RGD
involved in positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
15642789 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
12807724 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17483238 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16019103 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16689928 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
17056119 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17654247 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
12810531 RGD
involved in response to purine-containing compound IEP
IEP: Inferred from expression pattern
16759516 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
16273211 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
16298738 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16760380 RGD
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
15514162 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G1/S-specific cyclin-E1

  • cyclin E

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-145817A lunresertib Inhibitor 99.97% Phase 2
HY-170442 ECI830 Inhibitor 98.01% Phase 2
HY-160701 Cirtociclib 99.02% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175842 CDK2 degrader 7 Degrader 99.51% Unkown
HY-164827 CDK2 degrader 3 Degrader 99.91% Unkown
HY-162255 CDK2-IN-23 Inhibitor 99.29% Unkown
HY-159805 CDK2-IN-31 Inhibitor 98.22% Unkown
HY-RS02127 CCNE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180485 PROTAC D16-M1P2 / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-175819 PD-166285 / Unkown
HY-180196 EGFR-IN-187 / Unkown
HY-180484 PKMYT1-IN-12 Inhibitor / Unkown
HY-181004 PKMYT1-IN-13 Inhibitor / Unkown
HY-181131 Anticancer agent 300 / Unkown
HY-184649 CDK2-IN-60 Inhibitor / Unkown
HY-186126 CDK2 modulator 1 Modulator / Unkown
HY-186127 CCNE1 degrader-1 Degrader / Unkown
HY-186132 PROTAC CDK2-pRb degrader-1 Degrader / Unkown
HY-RS17273 Ccne1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23727 Ccne1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccne1 NCBI NCBI:898