KLK5 - kallikrein related peptidase 5 Gene

Also Known as SCTE; KLKL2; KLK-L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25818

About KLK5

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,943,303-50,953,038 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues and 12 paralogues. Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

KLK5 Products (3)

mRNA Protein Name
NM_001077491.2 NP_001070959.1 kallikrein-5 preproprotein
NM_001077492.2 NP_001070960.1 kallikrein-5 preproprotein
NM_012427.5 NP_036559.1 kallikrein-5 preproprotein

KLK5 Protein Structure

Trypsin

Trypsin: Trypsin (67 - 285)

  • 0
  • 100
  • 200
  • 293 a.a.
Protein Preferred Names Protein Names

kallikrein-5

  • kallikrein-like protein 2

KLK5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLK5 Q9Y337 FLG Homo sapiens P20930
Protease Assay
23629652
Intra
KLK5 Q9Y337 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra
KLK5 Q9Y337 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLK5 Proteins

Cat. No. Product Name Accession Purity
HY-P70939 Kallikrein-5 Protein, Human (HEK293, His, solution) Q9Y337 (V23-S293) ≥ 95%, as determined by reducing SDS-PAGE.

KLK5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83144 Kallikrein 5 Antibody (YA2889) WB, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Netherton Syndrome

  • NETH

  • Ns

  • Netherton Disease

  • Comel-Netherton Syndrome

  • Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

  • Bamboo Hair Syndrome

  • Ichthyosis Linearis Circumflexa

  • Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

  • Ilc

  • Nts

  • N Syndrome
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Telangiectasis

  • Telangiectasia
Ichthyosis, Congenital, Autosomal Recessive 4b

  • Harlequin Ichthyosis

  • Autosomal Recessive Congenital Ichthyosis 4b

  • Hi

  • Harlequin Fetus

  • ARCI4B

  • Ichthyosis Congenita, Harlequin Fetus Type

  • Harlequin Type Ichthyosis

  • 'Harlequin Fetus'

  • Harlequin Type Ichthyosis Congenita

  • Harlequin Type Ichthyosis Fetalis

  • Harlequin Baby Syndrome

  • Ichthyosis Congenita, Harlequin Type

  • Ichthyosis Fetalis, Harlequin Type

  • Ichthyosis Congenita Harlequin Fetus Type

  • Ichthyosis, Harlequin

  • Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Ichthyosis Vulgaris

  • Ichthyosis Simplex

  • Dominant Congenital Ichthyosiform Erythroderma

  • Common Ichthyosis

  • Fish Scale Disease

  • VI

  • Ichthyoses

  • Congenital Ichthyosis
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148949A Kallikrein 5-IN-2 TFA Inhibitor 99.53% Unkown
HY-P11840 KLK5-IN-1 Inhibitor / Unkown
HY-150085 GSK951 Inhibitor / Unkown
HY-124714 DKFZ-251 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KLK5 VGNC VGNC:42483
Mus musculus KLK5 MGD MGI:1915918
Felis catus KLK5 VGNC VGNC:67965
Rattus norvegicus KLK5 RGD RGD:1593461
Macaca mulatta KLK5 VGNC VGNC:74191
Bos taurus KLK5 VGNC VGNC:30679
Others KLK5 NCBI