2. Gene
  3. ULK3 - unc-51 like kinase 3 Gene

ULK3 - unc-51 like kinase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 25989 | Gene type: protein coding

About ULK3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,836,118-74,843,156 (from NCBI)

This gene has 24 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 31.2), small intestine (RPKM 22.9) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ULK3 Products(4)

mRNA Protein Name
NM_001099436.4 NP_001092906.3 serine/threonine-protein kinase ULK3 isoform a
NM_001284364.3 NP_001271293.2 serine/threonine-protein kinase ULK3 isoform b
NM_001284365.3 NP_001271294.1 serine/threonine-protein kinase ULK3 isoform c
NM_001411082.1 NP_001398011.1 serine/threonine-protein kinase ULK3 isoform d

ULK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 270)

MIT

MIT: MIT (microtubule interacting and transport) domain (281 - 347)

MIT

MIT: MIT (microtubule interacting and transport) domain (376 - 443)

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  • 472 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK3

Related Diseases

Diseases Alias
Non-Syndromic X-Linked Intellectual Disability 97

Mrx65

Mrx97

Mrxz

X-Linked Mental Retardation 65

X-Linked Mental Retardation 97
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-RS15457 ULK3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ULK3 VGNC VGNC:48130
Bos taurus ULK3 VGNC VGNC:36660
Felis catus ULK3 VGNC VGNC:66816
Macaca mulatta ULK3 VGNC VGNC:99339
Mus musculus ULK3 MGD MGI:1918992
Rattus norvegicus ULK3 RGD RGD:1587417