ULK3 - unc-51 like kinase 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25989

About ULK3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,836,118-74,843,156 (from NCBI)

This gene has 24 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 31.2), small intestine (RPKM 22.9) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ULK3 Products (4)

mRNA Protein Name
NM_001099436.4 NP_001092906.3 serine/threonine-protein kinase ULK3 isoform a
NM_001284364.3 NP_001271293.2 serine/threonine-protein kinase ULK3 isoform b
NM_001284365.3 NP_001271294.1 serine/threonine-protein kinase ULK3 isoform c
NM_001411082.1 NP_001398011.1 serine/threonine-protein kinase ULK3 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20643644 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19878745 GOA
Biological Process GO Annotation Evidence References Source
involved in fibroblast activation IMP
IMP: Inferred from mutant phenotype
28877478 GOA
involved in negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
20643644 GOA
involved in positive regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
19878745 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
19878745 GOA
involved in smoothened signaling pathway IDA
IDA: Inferred from direct assay
31279575 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19878745 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 270)

MIT

MIT: MIT (microtubule interacting and transport) domain (281 - 347)

MIT

MIT: MIT (microtubule interacting and transport) domain (376 - 443)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK3

ULK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ULK3 Q6PHR2 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra
ULK3 Q6PHR2 FKBP5 Homo sapiens Q13451
Pull Down
32707033
Intra
ULK3 Q6PHR2 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

ULK3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82610 ULK3 Antibody (YA2355) WB Human
HY-P82610A ULK3 Antibody (YA2355)(PBS only) WB Human
HY-P84640 ULK3 Antibody (YA4337) WB, IHC-P, ICC/IF, FC Human, Rat
HY-P84640A ULK3 Antibody (YA4337)(PBS only) WB, IHC-P, ICC/IF, FC Human, Rat

Related Diseases

Diseases Alias
Non-Syndromic X-Linked Intellectual Disability 97

  • Mrx65

  • Mrx97

  • Mrxz

  • X-Linked Mental Retardation 65

  • X-Linked Mental Retardation 97
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15457 ULK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19647 Ulk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26140 Ulk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ULK3 VGNC VGNC:48130
Bos taurus ULK3 VGNC VGNC:36660
Felis catus ULK3 VGNC VGNC:66816
Macaca mulatta ULK3 VGNC VGNC:99339
Mus musculus ULK3 MGD MGI:1918992
Rattus norvegicus ULK3 RGD RGD:1587417
Others ULK3 NCBI