CLEC4E - C-type lectin domain family 4 member E Gene

Also Known as MINCLE; CLECSF9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26253

About CLEC4E

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,533,305-8,540,905 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 14 paralogues. Biased expression in appendix (RPKM 10.3), spleen (RPKM 8.6) and 11 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC4E Products (2)

mRNA Protein Name
NM_001410969.1 NP_001397898.1 C-type lectin domain family 4 member E isoform 2
NM_014358.4 NP_055173.1 C-type lectin domain family 4 member E isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
24101491 GOA
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
24101491 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in pattern recognition receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24101491 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
24101491 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC4E Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (100 - 207)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member E

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9

Recombinant CLEC4E Proteins

Cat. No. Product Name Accession Purity
HY-P70118 CLEC4E Protein, Human (HEK293, His) Q9ULY5 (R41-L219) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Subcutaneous Mycosis

  • Subcutaneous Fungal Disease
Tinea Profunda

  • Deep Seated Dermatophytosis

  • Granuloma Trichophyticum

  • Majocchi'S Granuloma
Chromoblastomycosis

  • Chromomycosis

  • Mossy Foot Disease

  • Verrucous Dermatitis

  • Fonseca Disease

  • Pedroso Disease

  • Drechslera Hawaiiensis

  • Drechslera Infection
Phaeohyphomycosis

  • Infection By Dematiacious Fungi

  • Phaehyphomycosis

  • Phaeomycosis

  • Pheohyphomycosis

  • Infection By Dematiacious Fungi [Phaehyphomycosis]

  • Dematiaceous Fungal Infection
Dermatophytosis

  • Tinea

  • Dermatophytosis, Unspecified

  • Ringworm

  • Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

  • Cutaneous Mycosis

  • Dermal Mycosis

  • Superficial Mycosis, Unspecified

  • Fungus Infection Of Skin

  • Skin Mycosis

  • Dermatitis Fungoid

  • Fungal Dermatitis

  • Fungal Dermatosis

  • Mycotic Infection Of Skin
Vulvovaginal Candidiasis

  • Candidiasis Of Vulva And Vagina

  • Candidiasis, Vulvovaginal

  • Candidal Vulvovaginitis

  • Candidal: Cervix

  • Monilial Vulvovaginitis

  • Candidiasis Vulvovaginal
Superficial Mycosis

  • Piedra

  • Steroid-Modified Tinea Infection
Tinea Corporis

  • Dermatophytosis Of The Body

  • Dermatophytosis Of The Trunk
Pityriasis Versicolor

  • Tinea Versicolor

  • Infection By Pityrosporum Furfur
Blastomycosis

  • Gilchrist'S Disease

  • North American Blastomycosis

  • Blastomyces Dermatitidis Infection

  • Blastomycotic Infection

  • Infection By Blastomyces Dermatitidis

  • Gilchrist Disease

  • Chicago Disease

  • Chicago Disease Or Disorder

  • Blastomycosis, Unspecified

  • Blastomyces Infection
Candidal Paronychia

  • Candidiasis Of Skin

  • Candidiasis Of Skin And Nails

  • Candidal Perionyxis
Fungal Infectious Disease

  • Mycoses

  • Mycosis
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Primary Systemic Mycosis
Opportunistic Mycosis

  • Opportunistic Mycoses

  • Opportunistic Systemic Mycoses
Nail Disease

  • Nail Diseases

  • Abnormality Of The Nail

  • Nail Anomaly
Invasive Aspergillosis

  • Aspergillosis Invasive
Common Wart

  • Verruca Vulgaris

  • Viral Warts Nos

  • Filiform Warts

  • Digitate Warts
Tinea Capitis

  • Dermatophytosis Of Scalp

  • Scalp Ringworm

  • Dermatophytosis Of Scalp Or Beard

  • Tinea Capitis Due To Trichophyton Rubrum

  • Trichophyton Rubrum Tinea Capitis
Tinea Pedis

  • Athlete'S Foot

  • Dermatophytosis Of Foot

  • Ringworm Of Foot

  • Moccasin Foot
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02794 CLEC4E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17848 Clec4e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24316 Clec4e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLEC4E MGD MGI:1861232
Bos taurus CLEC4E VGNC VGNC:27432
Macaca mulatta CLEC4E VGNC VGNC:99916
Rattus norvegicus CLEC4E RGD RGD:1359298
Others CLEC4E NCBI