EHF - ETS homologous factor Gene

Also Known as ESE3; ESEJ; ESE3B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26298

About EHF

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,621,093-34,663,288 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 28 paralogues. Biased expression in esophagus (RPKM 89.9), colon (RPKM 60.6) and 12 other tissues.

Summary

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

EHF Products (19)

mRNA	Protein	Name
NM_001206615.2	NP_001193544.1	ETS homologous factor isoform 3
NM_001206616.2	NP_001193545.1	ETS homologous factor isoform 1 precursor
NM_001378041.1	NP_001364970.1	ETS homologous factor isoform 2
NM_001378042.1	NP_001364971.1	ETS homologous factor isoform 2
NM_001378043.1	NP_001364972.1	ETS homologous factor isoform 2
NM_001378044.1	NP_001364973.1	ETS homologous factor isoform 2
NM_001378045.1	NP_001364974.1	ETS homologous factor isoform 2
NM_001378046.1	NP_001364975.1	ETS homologous factor isoform 2
NM_001378047.1	NP_001364976.1	ETS homologous factor isoform 2
NM_001378048.1	NP_001364977.1	ETS homologous factor isoform 3
NM_001378049.1	NP_001364978.1	ETS homologous factor isoform 4
NM_001378050.1	NP_001364979.1	ETS homologous factor isoform 4
NM_001378051.1	NP_001364980.1	ETS homologous factor isoform 4
NM_001378052.1	NP_001364981.1	ETS homologous factor isoform 5 precursor
NM_001378053.1	NP_001364982.1	ETS homologous factor isoform 6
NM_001378054.1	NP_001364983.1	ETS homologous factor isoform 7
NM_001378055.1	NP_001364984.1	ETS homologous factor isoform 8
NM_001378056.1	NP_001364985.1	ETS homologous factor isoform 9
NM_012153.6	NP_036285.2	ETS homologous factor isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10644770	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10644770	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17027647	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	10644770	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10644770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHF Protein Structure

SAM_PNT

Ets

0
100
200
300 a.a.

Protein Preferred Names	Protein Names
ETS homologous factor	ESE3 transcription factor

EHF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EHF	Q9NZC4	KPRP	Homo sapiens	Q5T749	Anti Tag CoIP	33961781
Intra	EHF	Q9NZC4	KPRP	Homo sapiens	Q5T749	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Allergic Urticaria
Infiltrative Basal Cell Carcinoma	Skin Infiltrating Basal Cell Carcinoma
Milk Allergy	Milk Allergic Reaction Milk Hypersensitivity Allergy Milk
Cow Milk Allergy	Bos Taurus Milk Allergy Cow'S Milk Protein Sensitivity
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS04225	EHF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20680	Ehf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27191	Ehf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EHF	VGNC	VGNC:40249
Felis catus	EHF	VGNC	VGNC:102879
Macaca mulatta	EHF	VGNC	VGNC:72178
Mus musculus	EHF	MGD	MGI:1270840
Bos taurus	EHF	VGNC	VGNC:28375
Rattus norvegicus	EHF	RGD	RGD:1310282
Others	EHF	NCBI