Npc1 - NPC intracellular cholesterol transporter 1 Gene

Also Known as Cdig2; SLC66A1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266732

Summary

Predicted to enable Cholesterol binding activity. Involved in negative regulation of cell death and response to cadmium ion. Predicted to be located in several cellular components, including membrane raft; nuclear envelope; and perinuclear region of cytoplasm. Predicted to be integral component of lysosomal membrane and integral component of plasma membrane. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular Cholesterol transporter 1). [provided by Alliance of Genome Resources, Apr 2022]

Npc1 Products (1)

mRNA Protein Name
NM_153624.2 NP_705888.2 NPC intracellular cholesterol transporter 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22147702 RGD
involved in response to cadmium ion IDA
IDA: Inferred from direct assay
12890491 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NPC intracellular cholesterol transporter 1

  • Niemann-Pick disease, type C1

  • solute carrier family 66 member 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17376 Ezetimibe 99.95% Yes

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99544 Tagitanlimab Inhibitor ≥99.0% Phase 3
HY-P99362 Ensituximab Inhibitor 99.93% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110028 Leelamine hydrochloride 98.10% Unkown
HY-17376S Ezetimibe-d4 98.84% Unkown
HY-RS09474 NPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W395779 EBOV-IN-1 98.66% Unkown
HY-136059 Desfluoro-ezetimibe Activator 99.54% Unkown
HY-17376R Ezetimibe (Standard) 99.90% Unkown
HY-17640 Nicodicosapent Inhibitor 99.79% Unkown
HY-113845 (+)-Intermedine 99.0% Unkown
HY-17376S1 Ezetimibe-d4-1 99.26% Unkown
HY-135388 ent-Ezetimibe / Unkown
HY-160880 EBOV-IN-5 Inhibitor / Unkown
HY-160882 EBOV-IN-7 / Unkown
HY-160883 EBOV-IN-8 Inhibitor / Unkown
HY-17376S3 Ezetimibe-13C6 / Unkown
HY-182938 Autophagy activator-2 Activator / Unkown
HY-N18304 Brutieridin Inhibitor / Unkown
HY-RS09475 NPC1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121315 BRD4097 Inhibitor / Unkown
HY-157161 11β-HSD2-IN-1 Inhibitor / Unkown
HY-RS16778 Npc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17515 Npc1l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23218 Npc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23972 Npc1l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npc1 NCBI NCBI:4864