Sarm1 - sterile alpha and TIR motif containing 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287545

Summary

Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Predicted to be involved in several processes, including NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Predicted to act upstream of or within regulation of apoptotic process and response to glucose. Predicted to be located in microtubule; mitochondrion; and synapse. Predicted to be extrinsic component of mitochondrial outer membrane. Predicted to be active in dendrite. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Sarm1 Products (1)

mRNA Protein Name
NM_001105817.1 NP_001099287.1 NAD(+) hydrolase SARM1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in modification of postsynaptic structure IDA
IDA: Inferred from direct assay
21555464 RGD
involved in modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
21555464 RGD
Cellular Component GO Annotation Evidence References Source
is active in extrinsic component of synaptic membrane IDA
IDA: Inferred from direct assay
21555464 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21555464 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21555464 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD(+) hydrolase SARM1

  • NADP(+) hydrolase SARM1

  • NADase SARM1

  • sterile alpha and TIR motif-containing protein 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0985 Phenazopyridine hydrochloride Antagonist 99.55% Unkown
HY-B0985A Phenazopyridine Antagonist 99.93% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-129522 Sulfo-ara-F-NMN Activator 99.36% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W021879 DSRM-3716 Inhibitor 99.91% Unkown
HY-145917 SARM1-IN-2 Inhibitor 99.97% Unkown
HY-Z0816 Dehydronitrosonisoldipine Antagonist 98.86% Unkown
HY-128700 Nicotinic acid mononucleotide Activator 98.08% Unkown
HY-178159 SA91-0178 Inhibitor 98.14% Unkown
HY-128700A Nicotinic acid mononucleotide triethylamine Activator 99.89% Unkown
HY-171213 NB-3 Inhibitor 99.89% Unkown
HY-173276 SARM1-IN-4 Inhibitor / Unkown
HY-203012 NB-7 Inhibitor 99.82% Unkown
HY-172967 SARM1-IN-5 Inhibitor 99.93% Unkown
HY-161918 SARM1-IN-3 Inhibitor / Unkown
HY-172967A (R)-SARM1-IN-5 Control 97.68% Unkown
HY-176487 SARM1-IN-6 / Unkown
HY-182500 SARM1-IN-9 98.42% Unkown
HY-182500A (S,S)-SARM1-IN-9 Inhibitor 99.67% Unkown
HY-RS12446 SARM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175496 Acid Ceramidase-IN-3 Inhibitor / Unkown
HY-176783 GNE-5152 Inhibitor / Unkown
HY-179598 SARM1-IN-8 Inhibitor / Unkown
HY-182940 SARM1-IN-10 Inhibitor / Unkown
HY-RS16722 Sarm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23158 Sarm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008341 5-Chloroisoquinoline Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sarm1 NCBI NCBI:23098