SCG3 - secretogranin III Gene

Also Known as SGIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29106

About SCG3

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:51,681,503-51,721,026 (from NCBI)

This gene has 3 transcripts (splice variants) and 203 orthologues. Biased expression in brain (RPKM 94.6), adrenal (RPKM 8.5) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

SCG3 Products (2)

mRNA Protein Name
NM_001165257.2 NP_001158729.1 secretogranin-3 isoform 2
NM_013243.4 NP_037375.2 secretogranin-3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCG3 Protein Structure

SGIII

SGIII: Secretogranin-3 (17 - 468)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

secretogranin-3

SCG3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCG3 Q8WXD2 SDCBP Homo sapiens O00560
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCG3 Proteins

Cat. No. Product Name Accession Purity
HY-P71279 SCG3/Secretogranin-3 Protein, Human (HEK293, His) Q8WXD2-1 (F20-L468) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74568 SCG3/Secretogranin-3 Protein, Human (HEK293, His, solution) Q8WXD2-1 (F20-L468) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Motility-Related Diarrhea
Exudative Vitreoretinopathy 1

  • Retinopathy Of Prematurity

  • Retrolental Fibroplasia

  • EVR1

  • Criswick-Schepens Syndrome

  • Rop

  • Exudative Vitreoretinopathy, Familial, Autosomal Dominant

  • Fevr, Autosomal Dominant

  • Premature Retinopathy

  • Vitreoretinopathy, Exudative 1

  • Autosomal Dominant Familial Exudative Vitreoretinopathy

  • Fevr

  • Vitreoretinopathy, Exudative, Type 1

  • Retinopathy Of Prematurity Nos

  • Rlf- [Retrolental Fibroplasia]

  • Rop - [Retinopathy Of Prematurity]

  • Terry Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12502 SCG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19160 Scg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25649 Scg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SCG3 VGNC VGNC:34333
Canis familiaris SCG3 VGNC VGNC:45906
Rattus norvegicus SCG3 RGD RGD:621209
Mus musculus SCG3 MGD MGI:103032
Macaca mulatta SCG3 VGNC VGNC:77013
Felis catus SCG3 VGNC VGNC:64909
Others SCG3 NCBI