2. Gene
  3. Map4k2 - mitogen activated protein kinase kinase kinase kinase 2 Gene

Map4k2 - mitogen activated protein kinase kinase kinase kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 293694 | Gene type: protein coding

About Map4k2

Primary_assembly 1: 203,645,153-203,660,331 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 101 orthologues, 36 paralogues and is associated with 5 phenotypes. Biased expression in Thymus (RPKM 158.7), Lung (RPKM 156.9) and 9 other tissues.

Summary

Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; protein phosphorylation; and vesicle targeting. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map4k2 Products(1)

mRNA Protein Name
NM_001106329.1 NP_001099799.1 mitogen-activated protein kinase kinase kinase kinase 2

Map4k2 Protein Structure

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (15 - 271)

CNH

CNH: smart00036 (488 - 800)

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  • 821 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15434 NG25 Inhibitor 99.35% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-77251 TAK1/MAP4K2 inhibitor 1 Inhibitor 99.58% Unkown
HY-148061 DB1113 99.28% Unkown
HY-15434A NG25 trihydrochloride Inhibitor / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08076 Map4k2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k2 NCBI NCBI:5871