Ccl11 - C-C motif chemokine ligand 11 Gene

Also Known as Scya11

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29397

Summary

Enables chemokine activity. Involved in several processes, including ERK1 and ERK2 cascade; leukocyte chemotaxis; and response to interleukin-13. Located in extracellular space. Used to study allergic rhinitis; asthma; pleurisy; and pneumonia. Biomarker of several diseases, including allergic conjunctivitis; pneumonia; prostatitis; rhinitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11). [provided by Alliance of Genome Resources, Apr 2022]

Ccl11 Products (1)

mRNA Protein Name
NM_019205.2 NP_062078.1 eotaxin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
9458816 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
12413953 RGD
involved in actin filament organization IDA
IDA: Inferred from direct assay
12413953 RGD
involved in chronic inflammatory response IEP
IEP: Inferred from expression pattern
10861753 RGD
involved in eosinophil chemotaxis IDA
IDA: Inferred from direct assay
9458816 RGD
involved in eosinophil chemotaxis IMP
IMP: Inferred from mutant phenotype
9531320 RGD
involved in mast cell chemotaxis IDA
IDA: Inferred from direct assay
12413953 RGD
involved in response to interleukin-13 IEP
IEP: Inferred from expression pattern
15953562 RGD
involved in response to interleukin-4 IEP
IEP: Inferred from expression pattern
11071660 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9458816 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eotaxin

  • C-C motif chemokine 11

  • chemokine (C-C motif) ligand 11

  • eosinophil chemotactic protein

  • small inducible cytokine subfamily A11

  • small-inducible cytokine A11

Recombinant Ccl11 Proteins

Cat. No. Product Name Accession Purity
HY-P71901 CCL11 Protein, Rat P97545 (H24-P97) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99474 Bertilimumab Inhibitor 97.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2609 7,4'-Dihydroxyflavone Inhibitor 99.64% Unkown
HY-103361 SB297006 Antagonist 99.86% Unkown
HY-110295 SPL-334 Inhibitor 99.6% Unkown
HY-111198 YM-355179 fumarate / Unkown
HY-RS02081 CCL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174771 Human CCL11 mRNA / Unkown
HY-RS16897 Ccl11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23339 Ccl11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl11 NCBI NCBI:6356