Mag - myelin-associated glycoprotein Gene

Also Known as 1B236

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29409

Summary

Enables carboxylic acid binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath adaxonal region. Is integral component of plasma membrane. Used to study middle cerebral artery infarction and sciatic neuropathy. Biomarker of nerve compression syndrome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Mag Products (1)

mRNA	Protein	Name
NM_017190.4	NP_058886.1	myelin-associated glycoprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ganglioside GT1b binding	IDA IDA: Inferred from direct assay	8995428	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11733546	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18381654	RGD
enables sialic acid binding	IDA IDA: Inferred from direct assay	8995428	RGD
enables sialic acid binding	IMP IMP: Inferred from mutant phenotype	19420245	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	23132925	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	8995428	RGD
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	9298990	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	16140204	RGD
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	9298990	RGD
involved in negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	19349915	RGD
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	15282288	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	9298990	RGD
involved in nervous system development	IEP IEP: Inferred from expression pattern	2464408	RGD
involved in positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	19349915	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	12838505	RGD
located in mesaxon	IDA IDA: Inferred from direct assay	12838505	RGD
located in myelin sheath adaxonal region	IDA IDA: Inferred from direct assay	375239	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	9298990	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myelin-associated glycoprotein	S-MAG (C-term.) brain neuron cytoplasmic protein 3 sialic acid-binding Ig-like lectin 4a siglec-4a

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1498	Mag-Fluo-4 AM		≥96.0%	Unkown
HY-136924	FP-Biotin		99.08%	Unkown
HY-101898	Indo-1 AM		96%	Unkown
HY-10865	LY2183240	Inhibitor	98.04%	Unkown
HY-P10369	Betiatide		98.72%	Unkown
HY-112219A	H3R antagonist 1 hydrochloride	Inhibitor	99.10%	Unkown
HY-112219	H3R antagonist 1	Inhibitor	99.21%	Unkown
HY-146081	CD22 ligand-1	Ligand	/	Unkown
HY-D1700	Mag-indo-1/AM		/	Unkown
HY-D1701	Mag-Fura-2 AM		/	Unkown
HY-D1702	Mag-Fura-2 tetrapotassium		/	Unkown
HY-P11022	TL-119	Inhibitor	/	Unkown
HY-RS07963	MAG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07976	MAGED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07977	MAGED2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W127843	Mag-Indo-1 tetrapotassium salt		/	Unkown
HY-179748	7.7 MAG		/	Unkown
HY-179749	7.9 MAG		/	Unkown
HY-179800	8.8 MAG		/	Unkown
HY-179801	8.7 MAG		/	Unkown
HY-180407	UGM-IN-1	Inhibitor	/	Unkown
HY-RS17016	Mag Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23459	Mag Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mag	NCBI	NCBI:4099