Pdx1 - pancreatic and duodenal homeobox 1 Gene

Also Known as Idx1; Ipf1; Stf1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29535

Summary

Enables DNA-binding transcription factor activity; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; detection of glucose; and regulation of transcription, DNA-templated. Located in nucleus. Colocalizes with cytoplasm. Biomarker of acute necrotizing pancreatitis; hyperglycemia; placental insufficiency; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdx1 Products (1)

mRNA Protein Name
NM_022852.4 NP_074043.4 pancreas/duodenum homeobox protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
15151993 RGD
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10094480 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
19380737 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15001545 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
8524276 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10094480 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10094480 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15151993 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
17690043 RGD
involved in cell differentiation IMP
IMP: Inferred from mutant phenotype
11309388 RGD
involved in glucose mediated signaling pathway IDA
IDA: Inferred from direct assay
21108535 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17641871 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
18778483 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18253862 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11158595 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18439098 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10094480 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21108535 RGD
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
10802714 RGD
involved in response to L-leucine IEP
IEP: Inferred from expression pattern
19438972 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
15448089 RGD
involved in response to chlorate IEP
IEP: Inferred from expression pattern
17221210 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
16948396 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
17181874 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
15331541 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18230696 RGD
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
15148392 RGD
involved in response to iron(II) ion IEP
IEP: Inferred from expression pattern
16081762 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
17991758 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
18687784 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17882398 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19438972 RGD
involved in response to vitamin IEP
IEP: Inferred from expression pattern
11833042 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17991720 RGD
involved in smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
11181516 RGD
involved in stem cell differentiation IEP
IEP: Inferred from expression pattern
19382247 RGD
involved in stem cell differentiation IMP
IMP: Inferred from mutant phenotype
18253862 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15151993 RGD
involved in transdifferentiation IEP
IEP: Inferred from expression pattern
10952464 RGD
involved in type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
21108535 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pancreas/duodenum homeobox protein 1

  • IDX-1

  • IPF-1

  • Insulin promoter factor 1

  • STF-1

  • insulin promotor factor 1

  • islet/duodenum homeobox-1

  • pancreatic and duodenal homeobox gene 1

  • somatostatin transactivating factor 1

Pdx1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pdx1 P52947 Psmd9 Rattus norvegicus Q9WTV5
Y2H
15885879
Intra
Pdx1 P52947 Psmd9 Rattus norvegicus Q9WTV5
Pull Down
15885879
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19694 BRD7552 Activator 99.81% Unkown
HY-N0777 Isorhamnetin-3-O-glucoside 99.96% Unkown
HY-133668 Monoethyl phthalate Activator 98.58% Unkown
HY-133668S Monoethyl phthalate-d4 Activator 98.36% Unkown
HY-N19830 Guavenoic acid Inhibitor / Unkown
HY-RS10264 PDHX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10295 PDX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1130459 (R)-C12-200 / Unkown
HY-174547 Human PDX1 mRNA / Unkown
HY-RS20792 Pdx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21404 Pdhx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27306 Pdx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991294 MGTA-117 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdx1 NCBI NCBI:3651