DPM2 - Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29640

Summary

Enables dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme regulator activity. Acts upstream of or within GPI anchor biosynthetic process and dolichol metabolic process. Located in perinuclear region of cytoplasm. Part of dolichol-phosphate-mannose synthase complex. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Apr 2022]

DPM2 Products (1)

mRNA Protein Name
NM_019252.2 NP_062125.1 dolichol phosphate-mannose biosynthesis regulatory protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dolichyl-phosphate beta-D-mannosyltransferase activity IDA
IDA: Inferred from direct assay
9724629 RGD
enables enzyme regulator activity IDA
IDA: Inferred from direct assay
9724629 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10835346 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within GPI anchor biosynthetic process IDA
IDA: Inferred from direct assay
9724629 RGD
acts upstream of or within dolichol metabolic process IDA
IDA: Inferred from direct assay
9724629 RGD
Cellular Component GO Annotation Evidence References Source
part of dolichol-phosphate-mannose synthase complex IDA
IDA: Inferred from direct assay
9724629 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9724629 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9724629 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dolichol phosphate-mannose biosynthesis regulatory protein

  • DPM synthase subunit 2

  • dolichol-phosphate (beta-D) mannosyltransferase 2

  • dolichol-phosphate mannose synthase subunit 2

  • dolichol-phosphate mannosyltransferase 2

  • dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03959 DPM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21326 Dpm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27845 Dpm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DPM2 NCBI NCBI:8818