Bmal1 - basic helix-loop-helix ARNT like 1 Gene

Also Known as Arntl

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29657

Summary

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]

Bmal1 Products (1)

mRNA Protein Name
NM_024362.2 NP_077338.2 aryl hydrocarbon receptor nuclear translocator-like protein 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
9735336 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22356123 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22356123 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aryl hydrocarbon receptor nuclear translocator-like protein 1

  • brain and muscle ARNT-like 1

  • tic

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148765 CLK8 Inhibitor 98.06% Unkown
HY-14414 GSK4112 Inhibitor 99.87% Unkown
HY-148711 STL1267 Activator 99.83% Unkown
HY-115672 KS15 Inhibitor 99.46% Unkown
HY-N10319 Artepillin C 98.28% Unkown
HY-RS01529 BMAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176851 GSK1362 Inhibitor 96.38% Unkown
HY-RS23574 Bmal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17129 Bmal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmal1 NCBI NCBI:406
Mus musculus Bmal1 NCBI