OLA1 - Obg like ATPase 1 Gene

Also Known as DOC45; GBP45; GTBP9; GTPBP9; PTD004

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29789

About OLA1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,072,447-174,248,532 (from NCBI)

This gene has 9 transcripts (splice variants) and 281 orthologues. Ubiquitous expression in brain (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of Cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

OLA1 Products (3)

mRNA Protein Name
NM_001011708.3 NP_001011708.1 obg-like ATPase 1 isoform 2
NM_001328688.2 NP_001315617.1 obg-like ATPase 1 isoform 3
NM_013341.5 NP_037473.3 obg-like ATPase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
17430889 GOA
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
17430889 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
Biological Process GO Annotation Evidence References Source
involved in ATP metabolic process IDA
IDA: Inferred from direct assay
17430889 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLA1 Protein Structure

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (24 - 131)

YchF-GTPase_C

YchF-GTPase_C: Protein of unknown function (DUF933) (305 - 388)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

obg-like ATPase 1

  • DNA damage-regulated overexpressed in cancer 45 protein

OLA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89906 GTPBP9 Antibody (YA9250) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Hereditary Breast Ovarian Cancer Syndrome

  • Hereditary Breast And Ovarian Cancer Syndrome

  • Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

  • Breast And/Or Ovarian Cancer

  • Breast And Ovarian Cancer Syndrome

  • Hboc Syndrome

  • Hereditary Breast And Ovarian Cancer

  • Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09768 OLA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174563 Human OLA1 mRNA / Unkown
HY-RS18961 Ola1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25452 Ola1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OLA1 VGNC VGNC:97800
Rattus norvegicus OLA1 RGD RGD:1307982
Canis familiaris OLA1 VGNC VGNC:44112
Mus musculus OLA1 MGD MGI:1914309
Bos taurus OLA1 VGNC VGNC:32416
Others OLA1 NCBI