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  3. ALG5 - ALG5 dolichyl-phosphate beta-glucosyltransferase Gene

ALG5 - ALG5 dolichyl-phosphate beta-glucosyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PKD7; bA421P11.2

Gene ID: 29880 | Gene type: protein coding

About ALG5

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:36,949,738-36,999,367 (from NCBI)

This gene has 28 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 27.6), colon (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

ALG5 Products(2)

mRNA Protein Name
NM_001142364.1 NP_001135836.1 dolichyl-phosphate beta-glucosyltransferase isoform 2
NM_013338.5 NP_037470.1 dolichyl-phosphate beta-glucosyltransferase isoform 1

ALG5 Protein Structure

Glycos_transf_2

Glycos_transf_2: Glycosyl transferase family 2 (68 - 182)

  • 0
  • 100
  • 200
  • 300
  • 324 a.a.
Protein Preferred Names Protein Names

dolichyl-phosphate beta-glucosyltransferase

Alg5, S. cerevisiae, homolog of

Related Diseases

Diseases Alias
Polycystic Kidney Disease 7

PKD7
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12

Mrx35

X-Linked Mental Retardation 12

X-Linked Mental Retardation 35
Echinostomiasis

Infection By Echinochasmus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00594 ALG5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ALG5 RGD RGD:1308900
Felis catus ALG5 VGNC VGNC:59747
Macaca mulatta ALG5 VGNC VGNC:69647
Canis familiaris ALG5 VGNC VGNC:37799
Mus musculus ALG5 MGD MGI:1913498
Bos taurus ALG5 VGNC VGNC:25829