ALG5 - ALG5 dolichyl-phosphate beta-glucosyltransferase Gene

Also Known as PKD7; bA421P11.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29880

About ALG5

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:36,949,738-36,999,367 (from NCBI)

This gene has 28 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 27.6), colon (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the Glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

ALG5 Products (2)

mRNA	Protein	Name
NM_001142364.1	NP_001135836.1	dolichyl-phosphate beta-glucosyltransferase isoform 2
NM_013338.5	NP_037470.1	dolichyl-phosphate beta-glucosyltransferase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dolichyl-phosphate beta-glucosyltransferase activity	IGI IGI: Inferred from genetic interaction	10359825	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32353859	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dolichol-linked oligosaccharide biosynthetic process	IMP IMP: Inferred from mutant phenotype	10359825	GOA
involved in protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	10359825	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasmic side of rough endoplasmic reticulum membrane	IGI IGI: Inferred from genetic interaction	10359825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALG5 Protein Structure

Glycos_transf_2

0
100
200
300
324 a.a.

Protein Preferred Names	Protein Names
dolichyl-phosphate beta-glucosyltransferase	Alg5, S. cerevisiae, homolog of

ALG5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	ALG5	Q9Y673	ap3a_sars2	SARS-CoV-2	P0DTC3	Y2H Array	36217030

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polycystic Kidney Disease 7	PKD7
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome	Mrx12 Mrx35 X-Linked Mental Retardation 12 X-Linked Mental Retardation 35
Echinostomiasis	Infection By Echinochasmus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00594	ALG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALG5	RGD	RGD:1308900
Felis catus	ALG5	VGNC	VGNC:59747
Macaca mulatta	ALG5	VGNC	VGNC:69647
Canis familiaris	ALG5	VGNC	VGNC:37799
Mus musculus	ALG5	MGD	MGI:1913498
Bos taurus	ALG5	VGNC	VGNC:25829
Others	ALG5	NCBI