H2AC8 - H2A clustered histone 8 Gene

Also Known as H2A.1; H2A.2; H2A/a; H2AC4; H2AFA; HIST1H2AE

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 3012

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H2AC8 Products (1)

mRNA Protein Name
NM_021052.4 NP_066390.1 histone H2A type 1-B/E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20498094 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23956221 GOA
Cellular Component GO Annotation Evidence References Source
part of CENP-A containing nucleosome IPI
IPI: Inferred from physical interaction
21743476 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
20498094 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16319397 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H2A type 1-B/E

  • H2A histone family, member A

  • histone 1, H2ae

  • histone H2A/a

  • histone H2AE

  • histone cluster 1 H2A family member e

  • histone cluster 1, H2ae

H2AC8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H2AC4 P04908 H2BC15 Homo sapiens U3KQK0
Y2H Array
32296183
Intra
H2AC4 P04908 H2BC15 Homo sapiens U3KQK0
Y2H Prey Pooling
32296183
Intra
H2AC4 P04908 H2BC15 Homo sapiens U3KQK0
Validated Y2H
32296183
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
Anti Tag CoIP
33961781
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
3D-EM
31142837
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
X-Ray Diffraction
21743476
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
SAXS
21743476
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
X-Ray Diffraction
20498094
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
Comig Non-Denat Gel
21743476
Intra
H2AC4 P04908 H4C16 Homo sapiens P62805
GMS
20498094
Intra
H2AC4 P04908 H3-4 Homo sapiens Q16695
X-Ray Diffraction
20498094
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
X-Ray Diffraction
20498094
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
Comig Non-Denat Gel
21743476
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
GMS
20498094
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
Anti Tag CoIP
33961781
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
3D-EM
31142837
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
X-Ray Diffraction
21743476
Intra
H2AC4 P04908 H2BC11 Homo sapiens P06899
SAXS
21743476
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H2AC8 Proteins

Cat. No. Product Name Accession Purity
HY-P72328 H2AC4 Protein, Human P04908 (S2-K130) ≥ 95%, as determined by reducing SDS-PAGE.

H2AC8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80159 Histone H2A(acetyl K9) Antibody (YA382) WB, ICC/IF, IHC-P, ChIP Human, Mouse
HY-P80160 Histone H2A (hydroxyl Y39) Antibody (YA381) WB, IHC-P Human, Mouse
HY-P810651 Acetyl-Histone H2A (Lys9) Antibody (YA9911) WB, IHC-P, ICC/IF, ChIP Human, Mouse, Rat
HY-P83263 Histone H2A Antibody (YA3008) WB Human, Rat
HY-P83263A Histone H2A Antibody (YA3008)(PBS only) WB Human, Rat
HY-P83299 Acetyl-Histone H2A Antibody (YA3044) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83587 Hydroxyl-Histone H2A Antibody (YA3332) WB, IHC-P Human, Mouse
HY-P83587A Hydroxyl-Histone H2A Antibody (YA3332)(PBS only) WB, IHC-P Human, Mouse
HY-P86519 Histone H2A Antibody (YA6211) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06085 HDAC8 Human Pre-designed siRNA Set A / Unkown
HY-163920 PROTAC HDAC8 Degrader-1 Degrader / Unkown
HY-168175 PROTAC HDAC8 Degrader-2 Degrader / Unkown
HY-168176 HDAC8 ligand 1 Inhibitor / Unkown
HY-181023 PROTAC HDAC8 Degrader-3 Degrader / Unkown
HY-181024 PROTAC HDAC8 Degrader-4 Degrader / Unkown
HY-RS05955 H2AC18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06086 Hdac8 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06087 HDAC8 Rat Pre-designed siRNA Set A / Unkown