HBZ - hemoglobin subunit zeta Gene

Also Known as HBAZ; HBZ1; HBZ-T1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3050

About HBZ

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:152,644-154,503 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 11 paralogues. Biased expression in testis (RPKM 1.3), bone marrow (RPKM 0.5) and 1 other tissue.

Summary

Zeta-globin is an alpha-like Hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]

HBZ Products (1)

mRNA	Protein	Name
NM_005332.3	NP_005323.1	hemoglobin subunit zeta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	6683087	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in oxygen transport	IDA IDA: Inferred from direct assay	7543751	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of hemoglobin complex	IPI IPI: Inferred from physical interaction	6683087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HBZ Protein Structure

Globin

0
100
142 a.a.

Protein Preferred Names	Protein Names
hemoglobin subunit zeta	hemoglobin zeta chain

HBZ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HBZ	P02008	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	HBZ	P02008	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	HBZ	P02008	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	HBZ	P02008	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	HBZ	P02008	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	HBZ	P02008	DOCK8	Homo sapiens	Q8NF50-2	Y2H Prey Pooling	25416956
Intra	HBZ	P02008	HBQ1	Homo sapiens	P09105	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	HBQ1	Homo sapiens	P09105	Validated Y2H	32296183
Intra	HBZ	P02008	HBQ1	Homo sapiens	P09105	Y2H Array	32296183
Intra	HBZ	P02008	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	HBZ	P02008	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	HBZ	P02008	RBMY1A1	Homo sapiens	P0DJD3-2	Validated Y2H	32296183
Intra	HBZ	P02008	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	HBM	Homo sapiens	Q6B0K9	Validated Y2H	32296183
Intra	HBZ	P02008	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	HBZ	P02008	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	HBZ	P02008	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	HBZ	P02008	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	HBZ	P02008	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HBZ	P02008	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	HBZ	P02008	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	HBD	Homo sapiens	P02042	Validated Y2H	25416956
Intra	HBZ	P02008	HBD	Homo sapiens	P02042	Y2H Prey Pooling	25416956
Intra	HBZ	P02008	HBD	Homo sapiens	P02042	Validated Y2H	32296183
Intra	HBZ	P02008	HBD	Homo sapiens	P02042	Y2H Array	25416956
Intra	HBZ	P02008	HBE1	Homo sapiens	P02100	Validated Y2H	32296183
Intra	HBZ	P02008	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	HBZ	P02008	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	HBZ	P02008	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	HBB	Homo sapiens	P68871	Y2H Array	25502805
Intra	HBZ	P02008	HBB	Homo sapiens	P68871	Validated Y2H	32296183
Intra	HBZ	P02008	HBB	Homo sapiens	P68871	Electrophoresis	6683087
Intra	HBZ	P02008	HBB	Homo sapiens	P68871	Y2H Array	31515488
Intra	HBZ	P02008	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	HBZ	P02008	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	HBZ	P02008	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	HBZ	P02008	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	HBZ	P02008	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	31515488
Intra	HBZ	P02008	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	HBZ	P02008	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	HBZ	P02008	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	HBZ	P02008	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	HBZ	P02008	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	HBZ	P02008	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	HBZ	P02008	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	HBZ	P02008	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HBZ Proteins

Cat. No.	상품명	Accession	Purity
HY-P70242	Hemoglobin subunit zeta/HBAZ Protein, Human (His)	P02008 (M1-R142)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Adult T-Cell Leukemia/Lymphoma	Adult T-Cell Leukemia Atll Adult T-Cell Leukaemia Adult T-Cell Leukaemia/Lymphoma Adult T-Cell Lymphoma T Cell Leukemia Lymphoma Adult Leukemia-Lymphoma, Adult T-Cell Leukemia, T-Cell Adult T-Cell Lymphoma/Leukemia
Urethra Transitional Cell Carcinoma	Urethral Transitional Cell Carcinoma Urethral Urothelial Carcinoma
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Larynx Squamous Papilloma	Laryngeal Squamous Cell Papilloma
Tropical Spastic Paraparesis	Tropical Spastic Paraplegia Ham/Tsp Htlv-Associated Myelopathy Tropical Spastic Paralysis Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis Tsp Paraparesis Tropical Spastic Paraparesis, Tropical Spastic
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Histiocytosis-Lymphadenopathy Plus Syndrome	H Syndrome Histiocytosis With Joint Contractures And Sensorineural Deafness Faisalabad Histiocytosis Shml Hjcd Rosai-Dorfman Disease Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus Phid Sinus Histiocytosis And Massive Lymphadenopathy Familial Rosai-Dorfman Disease Slc29a3 Spectrum Disorder Sinus Histiocytosis With Massive Lymphadenopathy Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Rosai-Dorfman Disease, Familial Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness Rdd Rosaï-Dorfman Disease Slc29a3 Disorder Destombes-Rosai-Dorfman Disease Rosai-Dorfman-Destombes Disease HLAS Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness H Disease Sinus Histiocytosis
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Skin Papilloma	Cutaneous Papilloma Papilloma Of Skin Papilloma Skin
Strongyloidiasis	Disseminated Strongyloidiasis Anguilluliasis Anguillulosis Infection By Strongyloides Threadworm Infection Enterobiasis
Heinz Body Anemias	Heinz Body Anemia Heinz Body Anemias, Alpha- HEIBAN Anemia, Heinz Body Acquired Heinz Body Anemia
Hemoglobinopathy	Hemoglobinopathies
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS06036	HBZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26746	Hbz Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HBZ	MGD	MGI:96019
Rattus norvegicus	HBZ	RGD	RGD:1307486
Others	HBZ	NCBI