2. Gene
  3. S1pr3 - sphingosine-1-phosphate receptor 3 Gene

S1pr3 - sphingosine-1-phosphate receptor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Edg3; lpb3; Edg3l

Gene ID: 306792 | Gene type: protein coding

About S1pr3

Primary_assembly 17: 13,781,050-13,794,505 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 194 orthologues and 18 paralogues. Biased expression in Spleen (RPKM 11.), Lung (RPKM 9.) and 8 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity and Integrin binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of establishment of endothelial barrier; and regulation of metabolic process. Predicted to act upstream of or within several processes, including Notch signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and regulation of interleukin-1 beta production. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human S1PR3 (sphingosine-1-phosphate receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

S1pr3 Products(1)

mRNA Protein Name
NM_001271143.1 NP_001258072.1 sphingosine 1-phosphate receptor 3

S1pr3 Protein Structure

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (42 - 67)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (42 - 308)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (74 - 99)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (111 - 141)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (152 - 172)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (192 - 221)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (235 - 265)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (276 - 301)

  • 0
  • 100
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  • 300
  • 379 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 3

cardiac sphingosine-1-phosphate specific receptor

endothelial differentiation, sphingolipid G-protein-coupled receptor, 3

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 98.88% Yes
HY-10569 Ponesimod Agonist 99.81% Yes
HY-12355A Siponimod hemifumarate Agonist / Unkown
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119401 CAY10444 Antagonist ≥98.0% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% Unkown
HY-111253 CYM-5478 Agonist / Unkown
HY-108492 TC-SP 14 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr3 NCBI NCBI:1903