Sphk2 - sphingosine kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308589

About Sphk2

Primary_assembly 1: 96,180,887-96,188,391 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 209 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in Kidney (RPKM 86.5), Adrenal (RPKM 75.8) and 9 other tissues.

Summary

Predicted to enable kinase activity; nucleosomal histone binding activity; and sphingosine-1-phosphate receptor activity. Involved in female pregnancy. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human SphK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sphk2 Products (1)

mRNA Protein Name
NM_001012066.1 NP_001012066.1 sphingosine kinase 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18723875 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sphk2 Protein Structure

PLN02958

PLN02958: cl29912 (151 - 606)

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  • 616 a.a.
Protein Preferred Names Protein Names

sphingosine kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15779A K145 hydrochloride Inhibitor 99.63% Unkown
HY-12892 SKI-178 Inhibitor 99.29% Unkown
HY-147282 Amgen-23 Inhibitor 98.11% Unkown
HY-148707 SphK1&2-IN-1 Inhibitor 98.47% Unkown
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% Unkown
HY-151350 SphK2-IN-1 Inhibitor 99.61% Unkown
HY-150615 SphK1-IN-2 Inhibitor / Unkown
HY-120440 VT-ME6 Inhibitor / Unkown
HY-112385 ABC294735 Inhibitor / Unkown
HY-12896 SLR080811 Inhibitor / Unkown
HY-124368 RB-042 Inhibitor / Unkown
HY-120268 SLM6031434 Inhibitor / Unkown
HY-184272 SphK2-IN-5 Inhibitor / Unkown
HY-183338 SphK2-IN-4 Inhibitor / Unkown
HY-12897 (R)-FTY720-OMe Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sphk2 NCBI NCBI:56848