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SPHK2 - sphingosine kinase 2 Gene

Also Known as SK 2; SK-2; SPK 2; SPK-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56848

About SPHK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,619,506-48,630,405 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 6.4), duodenum (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and Apoptosis, and also plays a role in several types of Cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast Cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

SPHK2 Products (13)

mRNA	Protein	Name
XM_017027008.2	XP_016882497.1	sphingosine kinase 2 isoform X1
XM_011527134.2	XP_011525436.1	sphingosine kinase 2 isoform X3
XM_047439106.1	XP_047295062.1	sphingosine kinase 2 isoform X3
XM_011527133.2	XP_011525435.1	sphingosine kinase 2 isoform X2
NM_020126.5	NP_064511.2	sphingosine kinase 2 isoform a
NM_001204159.3	NP_001191088.1	sphingosine kinase 2 isoform a
NM_001204160.3	NP_001191089.1	sphingosine kinase 2 isoform c
NM_001204158.3	NP_001191087.1	sphingosine kinase 2 isoform b
XM_006723292.2	XP_006723355.1	sphingosine kinase 2 isoform X3
XM_047439107.1	XP_047295063.1	sphingosine kinase 2 isoform X4
NM_001243876.2	NP_001230805.1	sphingosine kinase 2 isoform d
XM_047439108.1	XP_047295064.1	sphingosine kinase 2 isoform X4
XM_017027010.3	XP_016882499.1	sphingosine kinase 2 isoform X4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D-erythro-sphingosine kinase activity	IDA IDA: Inferred from direct assay	10751414	GOA
enables histone binding	IDA IDA: Inferred from direct assay	19729656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11777919	GOA
enables sphingosine kinase activity	IDA IDA: Inferred from direct assay	19729656	GOA
enables sphingosine-1-phosphate receptor activity	IMP IMP: Inferred from mutant phenotype	23106337	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	17635916	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16118219	GOA
involved in positive regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	16118219	GOA
involved in regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	20959514	GOA
involved in sphinganine-1-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	10751414	GOA
involved in sphingosine biosynthetic process	IGI IGI: Inferred from genetic interaction	23106337	GOA
involved in sphingosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	19729656	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16103110	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10751414	GOA
located in membrane	IDA IDA: Inferred from direct assay	10751414	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	19729656	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16103110	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPHK2 Protein Structure

DAGK_cat

0
200
400
600
654 a.a.

Protein Preferred Names	Protein Names
sphingosine kinase 2

SPHK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

SPHK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85786	SphK2 Antibody (YA5478)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ureteral Obstruction
Brachydactyly, Type E1	Brachydactyly Type E1 Brachydactyly Type E BDE1 Brachydactyly, Type E Bde Type E Brachydactyly Brachydactyly E1 Brachydactyly Syndrome Type E

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15779A	K145 hydrochloride	Inhibitor	99.63%	Unkown
HY-12892	SKI-178	Inhibitor	99.29%	Unkown
HY-147282	Amgen-23	Inhibitor	98.11%	Unkown
HY-148707	SphK1&2-IN-1	Inhibitor	98.47%	Unkown
HY-120268A	SLM6031434 hydrochloride	Inhibitor	99.1%	Unkown
HY-151350	SphK2-IN-1	Inhibitor	99.61%	Unkown
HY-150615	SphK1-IN-2	Inhibitor	/	Unkown
HY-120440	VT-ME6	Inhibitor	/	Unkown
HY-112385	ABC294735	Inhibitor	/	Unkown
HY-12896	SLR080811	Inhibitor	/	Unkown
HY-124368	RB-042	Inhibitor	/	Unkown
HY-120268	SLM6031434	Inhibitor	/	Unkown
HY-184272	SphK2-IN-5	Inhibitor	/	Unkown
HY-183338	SphK2-IN-4	Inhibitor	/	Unkown
HY-12897	(R)-FTY720-OMe	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPHK2	VGNC	VGNC:35211
Rattus norvegicus	SPHK2	RGD	RGD:1307757
Macaca mulatta	SPHK2	VGNC	VGNC:77960
Mus musculus	SPHK2	MGD	MGI:1861380
Canis familiaris	SPHK2	VGNC	VGNC:46737
Others	SPHK2	NCBI